Document Detail

Pulsus alternans induced by glyceryl trinitrate paste in a patient with alcoholic cardiomyopathy.
MedLine Citation:
PMID:  154916     Owner:  NLM     Status:  MEDLINE    
Application of a small dose of glyceryl trinitrate paste (0.25 in) resulted in severe left ventricular dysfunction with the appearance of pulsus alternans in a patient with alcoholic cardiomyopathy. The echocardiogram showed a reduction in the amplitude and velocity of motion of the left ventricular posterior wall on alternate beats. Leg elevation promptly reversed the pulsus alternans, and the echocardiographic abnormality. Glyceryl trinitrate paste should be used with caution and under close supervision in patients with liver dysfunction.
P A Chandraratna; E Langevin; J Langevin
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  British heart journal     Volume:  41     ISSN:  0007-0769     ISO Abbreviation:  Br Heart J     Publication Date:  1979 Mar 
Date Detail:
Created Date:  1979-06-29     Completed Date:  1979-06-29     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370634     Medline TA:  Br Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  354-5     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Pressure / drug effects
Cardiomegaly / etiology
Cardiomyopathy, Alcoholic / complications*,  diagnosis,  drug therapy
Heart Failure / drug therapy*,  etiology
Hepatitis, Alcoholic / complications
Myocardial Contraction / drug effects
Nitroglycerin / adverse effects*,  pharmacology,  therapeutic use
Pulse / drug effects*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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