Document Detail

Pulseless (Takayasu) disease with ophthalmic manifestations.
MedLine Citation:
PMID:  7906698     Owner:  NLM     Status:  MEDLINE    
Pulseless disease (PD) is a rare disorder in which inflammation of the aorta and its major branches leads to stenosis or occlusion of these arteries. It mainly affects young Oriental women, who suffer chronic ischemic injury to tissues of the brain, orbits, upper limbs, myocardium, and kidneys. The ophthalmologic features of pulseless disease tend to be late manifestations, and can include ischemia of the retina, choroid, and anterior segment. The inflammatory process may be reversed in early stages with systemic corticosteroids, but, more frequently, significant arterial stenosis necessitates arterial bypass surgery. A 59-year-old Caucasian woman with stenosis of all four major cervical arteries presented with recurrent blurred vision, syncope, mental obtundation, and a remarkable funduscopic appearance due to bilateral orbital hypoperfusion. Her acute symptoms improved slightly on high-dose systemic corticosteroids, and then resolved completely following arterial bypass surgery.
J R Lewis; J S Glaser; N J Schatz; D G Hutson
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical neuro-ophthalmology     Volume:  13     ISSN:  0272-846X     ISO Abbreviation:  J Clin Neuroophthalmol     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1994-03-28     Completed Date:  1994-03-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8109051     Medline TA:  J Clin Neuroophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  242-9     Citation Subset:  IM    
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, Florida 33101.
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MeSH Terms
Arterial Occlusive Diseases / etiology
Brain Ischemia / etiology
Eye / blood supply*
Ischemia / diagnosis,  etiology*
Middle Aged
Takayasu Arteritis / complications*

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