Document Detail

Pulsed-light imaging for fluorescence guided surgery under normal room lighting.
MedLine Citation:
PMID:  23988926     Owner:  NLM     Status:  MEDLINE    
Fluorescence guided surgery (FGS) is an emerging technology that has demonstrated improved surgical outcomes. However, dim lighting conditions required by current FGS systems are disruptive to standard surgical workflow. We present a novel FGS system capable of imaging fluorescence under normal room light by using pulsed excitation and gated acquisition. Images from tissue-simulating phantoms confirm visual detection down to 0.25 μM of protoporphyrin IX under 125 μW/cm2 of ambient light, more than an order of magnitude lower than that measured with the Zeiss Pentero in the dark. Resection of orthotopic brain tumors in mice also suggests that the pulsed-light system provides superior sensitivity in vivo.
Kristian Sexton; Scott C Davis; David McClatchy; Pablo A Valdes; Stephen C Kanick; Keith D Paulsen; David W Roberts; Brian W Pogue
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Optics letters     Volume:  38     ISSN:  1539-4794     ISO Abbreviation:  Opt Lett     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-08-30     Completed Date:  2014-04-29     Revised Date:  2014-06-11    
Medline Journal Info:
Nlm Unique ID:  7708433     Medline TA:  Opt Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3249-52     Citation Subset:  IM    
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MeSH Terms
Glioma / surgery
Surgery, Computer-Assisted / methods*
Grant Support
P01 CA084203/CA/NCI NIH HHS; R01 CA109558/CA/NCI NIH HHS; R01 CA109558/CA/NCI NIH HHS

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