Document Detail


Pulsed laser versus electrical energy for peripheral nerve stimulation.
MedLine Citation:
PMID:  17537515     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Transient optical neural stimulation has previously been shown to elicit highly controlled, artifact-free potentials within the nervous system in a non-contact fashion without resulting in damage to tissue. This paper presents the physiologic validity of elicited nerve and muscle potentials from pulsed laser induced stimulation of the peripheral nerve in a comparative study with the standard method of electrically evoked potentials. Herein, the fundamental physical properties underlying the two techniques are contrasted. Key laser parameters for efficient optical stimulation of the peripheral nerve are detailed. Strength response curves are shown to be linear for each stimulation modality, although fewer axons can be recruited with optically evoked potentials. Results compare the relative transient energy requirements for stimulation using each technique and demonstrate that optical methods result in highly selective functional nerve stimulation. Adjacent stimulation and recording of compound nerve potentials in their entirety from optical and electrical stimulation are presented, with optical responses shown to be free of any stimulation artifact. Thus, use of a pulsed laser exhibits distinct advantages when compared to standard electrical means for excitation of muscle potentials in the peripheral nerve in the research domain and possibly for clinical diagnostics in the future.
Authors:
Jonathon Wells; Peter Konrad; Chris Kao; E Duco Jansen; Anita Mahadevan-Jansen
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-03-31
Journal Detail:
Title:  Journal of neuroscience methods     Volume:  163     ISSN:  0165-0270     ISO Abbreviation:  J. Neurosci. Methods     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-06-11     Completed Date:  2007-09-27     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  7905558     Medline TA:  J Neurosci Methods     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  326-37     Citation Subset:  IM    
Affiliation:
Vanderbilt University, Department of Biomedical Engineering, 5824 Stevenson Center, Nashville, TN 37235, United States.
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / physiology,  radiation effects
Animals
Artifacts
Electric Stimulation / methods
Electrophysiology / instrumentation,  methods*
Infrared Rays
Lasers / standards*
Muscle Contraction / physiology
Muscle, Skeletal / innervation,  physiology
Neural Conduction / physiology,  radiation effects
Optics and Photonics / instrumentation*
Peripheral Nerves / physiology*,  radiation effects*
Rats
Rats, Sprague-Dawley
Sciatic Nerve / physiology,  radiation effects
Time Factors
Grant Support
ID/Acronym/Agency:
R01 NS052407-01/NS/NINDS NIH HHS; R01 NS052407-02/NS/NINDS NIH HHS
Comments/Corrections

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