Document Detail

Pulsed laser light forces cancer cells to absorb anticancer drugs - the role of water in nanomedicine.
MedLine Citation:
PMID:  20849242     Owner:  NLM     Status:  In-Data-Review    
Abstract: Anticancer drugs executing their function intracellularly enter cancer cells via diffusive processes. Complementary to these slow processes, cells can be forced to incorporate drugs by convection - a more efficient transport process. Transmembrane convection is induced by moderately intense pulsed laser light (or light emitting diodes) changing the structure of nanoscopic water layers in cells. This is a fundamental difference with the method of photodynamic therapy. In a model system we demonstrate that a total irradiation time of one minute is sufficient to completely inhibit proliferation of cancer cells. Transmembrane convection protects healthy cells from extended chemotherapy exposure, could be exploited to overcome multidrug resistance, and is a promising new tool in a variety of therapies as well as in skin rejuvenation.
Andrei P Sommer; Dan Zhu; Adam R Mester; Horst-Dieter Försterling
Publication Detail:
Type:  Journal Article     Date:  2010-09-17
Journal Detail:
Title:  Artificial cells, blood substitutes, and immobilization biotechnology     Volume:  39     ISSN:  1532-4184     ISO Abbreviation:  Artif Cells Blood Substit Immobil Biotechnol     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9431307     Medline TA:  Artif Cells Blood Substit Immobil Biotechnol     Country:  England    
Other Details:
Languages:  eng     Pagination:  169-73     Citation Subset:  IM    
Institute of Micro and Nanomaterials, University of Ulm, Ulm, Germany.
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