| Pulse width is associated with cognitive decline after thalamic stimulation for essential tremor. | |
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MedLine Citation:
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PMID: 12781597 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study sought to identify predictors of cognitive decline after thalamic deep brain stimulation (DBS) for essential tremor (ET). Twenty-seven patients (55%) with ET demonstrated mild cognitive decrements relative to pre-surgical baseline (ET-D), whereas 22 patients (45%) were classified as neuropsychologically stable (ET-S). The ET-D and ET-S groups were comparable in terms of baseline demographic, disease, and neuropsychological characteristics, as well as post-surgical motor outcomes. However, the ET-D group had significantly higher pulse width (PW) stimulator settings, and a greater proportion of ET-D than ET-S patients underwent left in comparison to right thalamic stimulation. A subsequent step-wise discriminant function analysis revealed that disease onset after age 37 years and higher PW settings (>or=120 micros) were the strongest predictors of post-surgical cognitive decline in this sample. Findings indicate that although relatively higher PW settings might afford optimal tremor control in some patients, the corresponding risk of mild, probably often subclinical, cognitive morbidity must be weighed accordingly. |
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Authors:
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Steven Paul Woods; Julie A Fields; Kelly E Lyons; Rajesh Pahwa; Alexander I Tröster |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Parkinsonism & related disorders Volume: 9 ISSN: 1353-8020 ISO Abbreviation: Parkinsonism Relat. Disord. Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-06-03 Completed Date: 2003-07-29 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9513583 Medline TA: Parkinsonism Relat Disord Country: England |
Other Details:
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Languages: eng Pagination: 295-300 Citation Subset: IM |
Affiliation:
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Department of Psychiatry and Behavioral Sciences, School of Medicine, University of Washington, Box 356560, 1959 NE Pacific Street, Seattle, WA 98195-6560, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cognition Disorders / diagnosis, etiology* Electric Stimulation Therapy / adverse effects*, methods Essential Tremor / physiopathology, therapy* Female Humans Male Neuropsychological Tests Thalamus / physiopathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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