Document Detail


Pulse wave velocity in retinal arteries of healthy volunteers.
MedLine Citation:
PMID:  21041458     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Background/aims Measurement of pulse wave velocity (PWV) in large vessels has been used extensively in clinical practice as an indirect measure of arterial stiffness and an indicator of cardiovascular risk factors. Arterial stiffness increases with age and in coronary artery disease. An in vivo clinical method to characterise arterial stiffness of the central microcirculation was developed. Methods Time-dependent alterations of retinal vessel diameter were examined by the dynamic vessel analyzer in a randomly chosen eye of 10 young (26.0 (23.5, 27.0) years old (median (1st quartile, 3rd quartile)) and 10 old (67.0 (61.3, 69.5)) years old) healthy volunteers. Two segments of a retinal artery were measured simultaneously. The distance between the segments was measured using retinal photographs. The data were filtered and analysed using signal analysis methods in order to calculate PWV in the assessed retinal artery (rPWV). Results rPWV differed significantly between young (21.5 (17.9, 4.6) mm/s) and old (243.8 (186.1, 347.7) mm/s) volunteers: (p=0.0001, Mann-Whitney test with Bonferroni correction). Conclusions This study demonstrates a higher rPWV in elderly people than in young people. Therefore this new parameter resembles large artery PWV. This suggests that dynamic in vivo imaging of the central microcirculation enables the measurement of local microvascular stiffness with a commercially available medical device.
Authors:
Konstantin E Kotliar; Marcus Baumann; Walthard Vilser; Ines M Lanzl
Related Documents :
2422618 - Relative afferent pupillary defect in central retinal vein occlusion.
1098468 - The incidence of retinal detachment after penetrating keratoplasty.
10907168 - Elucidation of vascular structure of molar villi in complete hydatidiform mole by cd-34...
10877378 - Relationship between the effect of carbon dioxide inhalation or nilvadipine on orbital ...
20529518 - Conservative management of bronchopulmonary artery perforation without associated haemo...
10543628 - Disseminated coccidioidomycosis complicated by vasculitis: a cause of fatal subarachnoi...
Publication Detail:
Type:  Journal Article     Date:  2010-11-01
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  95     ISSN:  1468-2079     ISO Abbreviation:  Br J Ophthalmol     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  675-9     Citation Subset:  IM    
Affiliation:
Department of Nephrology, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str, 22, 81675 Munich, Germany; kotliar@lrz.tum.de.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Intraocular pressure during laparoscopic surgery in paediatric patients.
Next Document:  Periorbital lipogranuloma: a previously unknown complication of autologous fat injections for facial...