| Pulse wave analysis and prevalent cardiovascular disease in type 1 diabetes. | |
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MedLine Citation:
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PMID: 20880527 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Type 1 diabetes (T1D) is associated with a high risk for and mortality from premature coronary artery disease (CAD), including coronary artery calcification (CAC), a subclinical marker, and lower extremity arterial disease (LEAD). Pulse wave analysis (PWA) arterial stiffness indices have been associated with cardiovascular disease (CVD) risk factors and outcomes in various populations, but little is known regarding these relationships in T1D. METHODS: PWA was performed using the SphygmoCor Px device on 144 participants in the Pittsburgh EDC Study of childhood-onset T1D. The cross-sectional associations between arterial stiffness indices, augmentation index (AIx) and augmentation pressure (AP), and subendocardial viability ratio (SEVR), an estimate of myocardial perfusion, with prevalent CAD, electron beam computed tomography-measured CAC and low (<0.90) ankle-brachial index (ABI) were examined. RESULTS: Higher AP (but not AIx) and lower SEVR were univariately associated with prevalent CAD, high CAC score, and low ABI. AP and SEVR's association with CAD and CAC did not, however, remain significant after adjustment for age. In individuals not using nitrates, which profoundly affect PWA measures, AP was significantly higher in those with CAD events and explained more of the variance than either age or brachial blood pressure measures. SEVR was associated with low ABI in multivariable models. CONCLUSIONS: Greater augmentation pressure is independently associated with prevalent CAD and estimated myocardial perfusion with low ABI in type 1 diabetes. These measures may thus help to better characterize CVD risk in type 1 diabetes and need to be examined prospectively. |
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Authors:
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Catherine T Prince; Aaron M Secrest; Rachel H Mackey; Vincent C Arena; Lawrence A Kingsley; Trevor J Orchard |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-09-15 |
Journal Detail:
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Title: Atherosclerosis Volume: 213 ISSN: 1879-1484 ISO Abbreviation: Atherosclerosis Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-06 Completed Date: 2011-03-18 Revised Date: 2011-12-21 |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
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Languages: eng Pagination: 469-74 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, United States. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Flow Velocity Calcinosis / radiography Cardiovascular Diseases / epidemiology*, radiography Cardiovascular Physiological Phenomena Coronary Artery Disease / physiopathology, radiography Diabetes Mellitus, Type 1 / complications, physiopathology*, radiography Female Humans Male Middle Aged Pennsylvania / epidemiology Prevalence Pulsatile Flow Tomography, X-Ray Computed Vascular Resistance |
| Grant Support | |
ID/Acronym/Agency:
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F30 DK082137-04/DK/NIDDK NIH HHS; F30-DK082137/DK/NIDDK NIH HHS; R01 DK034818-24/DK/NIDDK NIH HHS; R01-DK034818/DK/NIDDK NIH HHS |
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