| Pulse wave analysis in a pilot randomised controlled trial of auto-adjusting and continuous positive airway pressure for obstructive sleep apnoea. | |
| | |
MedLine Citation:
|
PMID: 20628825 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
PURPOSE: Non-invasive measurements of arterial stiffness including the augmentation index (AIx) and central blood pressure (BP) have been used to assess the cardiovascular health of patients with obstructive sleep apnoea (OSA), a well-established independent risk factor of cardiovascular disease. Continuous positive airway pressure (CPAP) can significantly reduce the AIx, but no studies have analysed the effect of auto-adjusting PAP (APAP) or studied morbidly obese patients with severe OSA at higher risk of cardiovascular disease. In this randomised, single-blinded crossover pilot trial, we aimed to compare the efficacy of CPAP with APAP (ResMed S8 Autoset II) in improving peripheral BP, central BP and the AIx, using SphygmoCor technology. METHODS: Twelve severe OSA patients (mean±SD; apnoea-hypopnoea index, 75.8 ± 32.7; BMI, 49.9 ± 5.2 kg/m(2)) were consecutively recruited and received CPAP (mean pressure, 16.4 cm H(2)O) or APAP in random order for four nights at home, separated by a four-night washout. Cardiovascular measurements were taken at baseline, post-washout and following each treatment arm. RESULTS: The polysomnographically recorded residual apnoea-hypopnoea index and compliance to treatment were not significantly different between arms (p > 0.05). There were no significant differences in peripheral or central BP between arms (p > 0.05). The AIx was lower with CPAP than APAP (by 5.8%), with a large effect size not reaching statistical significance (r = 0.61, p = 0.14). CONCLUSION: The large effect size evident when comparing the AIx following CPAP and APAP indicates the need to perform an adequately powered trial in order to determine if APAP improves arterial stiffness to the same extent as CPAP. |
| | |
Authors:
|
Jessie P Bakker; Angela J Campbell; Alister M Neill |
Related Documents
:
|
16430795 - Comparison of the laryngeal mask (lma) and laryngeal tube (lt) with the new perilarynge... 3189995 - Effects of ventriculectomy, prosthetic laryngoplasty, and exercise on upper airway func... 12918905 - Nonlinear mechanisms determining expiratory flow limitation in mechanical ventilation: ... 190205 - Neonatal chest wall afferents and regulation of respiration. 8332995 - Central and peripheral cardio-respiratory effects of saxitoxin (stx) in urethane-anesth... 23027065 - Treatment options for intrinsic sphincter deficiency. |
Publication Detail:
|
Type: Journal Article Date: 2010-07-14 |
Journal Detail:
|
Title: Sleep & breathing = Schlaf & Atmung Volume: 15 ISSN: 1522-1709 ISO Abbreviation: Sleep Breath Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-10-03 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9804161 Medline TA: Sleep Breath Country: Germany |
Other Details:
|
Languages: eng Pagination: 325-32 Citation Subset: IM |
Affiliation:
|
WellSleep Sleep Investigation Centre, Department of Medicine, University of Otago, Wellington, New Zealand, jessie.bakker@otago.ac.nz. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: S100B Protein Expressions as an Independent Predictor of Early Relapse in UICC Stages II and III Col...
Next Document: Erectile tissue molecular alterations with aging: differential activation of the p42/44 MAP Kinase p...