Document Detail


Pulse wave amplitude is associated with brachial artery diameter: implications for gender differences in microvascular function.
MedLine Citation:
PMID:  20026517     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ratio of pulse wave amplitude (PWA) during reactive hyperemia compared to baseline as measured by peripheral arterial tonometry (PAT) is a non-invasive measure of microvascular endothelial function referred to as the pulse wave amplitude reactive hyperemia index (PWA-RHI). Whether upstream conduit vessel structure may affect downstream resistance vessel PWA has not been clearly examined. We tested the hypothesis that digital PWA is influenced by brachial artery diameter (BAD) and that this association would influence comparison of PWA-RHI between genders. Measures of vascular structure and microvascular function were carried out in 115 patients varying in cardiovascular risk profiles (average age 57 years, male n = 79, CAD n = 43). PWA was assessed using plethysmography at baseline and following 5 minutes of brachial artery occlusion. BAD was assessed using high-resolution ultrasonography. Results : There was a negative association between BAD and PWA-RHI ( r = -0.34, p < 0.05). Women had greater PWA-RHI and smaller BAD compared with men (p < 0.05). When co-varying for BAD, there were no longer gender differences in PWA-RHI. Moreover, when a sub-group of men and women without CAD (n = 40), matched for BAD, were examined, there were no gender differences in PWA-RHI. In conclusion, PWA-RHI obtained from PAT is associated with BAD. Studies examining gender differences in microvascular endothelial function with PAT may need to correct for BAD as a potential confounder.
Authors:
Kevin S Heffernan; Richard H Karas; Paula J Mooney; Ayan R Patel; Jeffrey T Kuvin
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2009-12-21
Journal Detail:
Title:  Vascular medicine (London, England)     Volume:  15     ISSN:  1477-0377     ISO Abbreviation:  Vasc Med     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-22     Completed Date:  2010-04-02     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  9610930     Medline TA:  Vasc Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  39-45     Citation Subset:  IM    
Affiliation:
Vascular Function Study Group, Department of Medicine, Division of Cardiology, Tufts Medical Center, Boston, MA 02111, USA. kheffernan@tuftsmedicalcenter.org
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MeSH Terms
Descriptor/Qualifier:
Brachial Artery / physiopathology*,  ultrasonography
Cardiovascular Diseases / diagnosis*,  physiopathology,  ultrasonography
Endothelium, Vascular / physiopathology*
Female
Humans
Hyperemia / physiopathology
Logistic Models
Male
Manometry
Microcirculation*
Middle Aged
Plethysmography
Predictive Value of Tests
Pulsatile Flow*
ROC Curve
Sex Factors
Vasodilation*
Grant Support
ID/Acronym/Agency:
T32 HL069770-06A1/HL/NHLBI NIH HHS
Comments/Corrections

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