Document Detail

Pulse-wave Doppler Tissue Imaging in the assessment of regional left ventricular diastolic function in patients with coronary artery disease
MedLine Citation:
PMID:  20582886     Owner:  NLM     Status:  MEDLINE    
AIM: Myocardial ischemia impairs the diastolic left ventricular (LV) function earlier than the systolic function. We evaluated the value of pulse-wave Doppler Tissue Imaging (DTI) in the study of regional myocardial function of LV in patients with coronary artery disease. METHODS: We performed a prospective study in 60 patients with coronary artery disease that we compared to 40 healthy individuals in order to assess the value of pulse-wave DTI to study the diastolic LV function . Both groups had a clinical examination, ECG, echocardiography and pulse-wave DTI. Only the patients had a coronary angiography. Pulse-wave DTI was applied to the 16 myocardial segments of the LV, we measured the isovolumetric relaxation time (IVRT), early (Ea) and late diastolic (Aa) velocities. RESULTS: We have demonstrated that compared with healthy subjects, patients with coronary artery disease has a significant increase of IVRT (100.2 +/- 20 ms vs 62.5 +/- 12.2, p <0.001) and lower Ea (7.6 +/- 1.6 vs. 9.2 +/- 2.6) and report Ea / Aa. These anomalies are more pronounced in akinetic segments compared with hypokinetic segments. Relying on data from the coronary angiography, we found in patients that IVRT had increased, Ea and Ea / Aa lowered in most segments hypoperfused than in normally perfused segments. An IVRT > 70ms and Ea <8.3 cm / s emerge as threshold values to identify myocardial ischemia. More coronary lesions are severe more Ea and Ea/Aa decline and IVRT increase. The culprit coronary artery could be identified by pulse- wave DTI since the DTI parameter anomalies are systemized CONCLUSION: The pulsed DTI technique seems to be attractive as a non-invasive evaluation method of ischemic heart disease.
Sana Fennira; Fathia Ben Moussa; Yassine Ellouze; Sondos Kraiem; Med Lotfi Slimane
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Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  La Tunisie médicale     Volume:  88     ISSN:  0041-4131     ISO Abbreviation:  Tunis Med     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-28     Completed Date:  2010-09-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0413766     Medline TA:  Tunis Med     Country:  Tunisia    
Other Details:
Languages:  fre     Pagination:  492-6     Citation Subset:  IM    
Service de Cardiologie, Hôpital Habib Thameur, Tunis.
Vernacular Title:
Intérêt du doppler tissulaire dans l'évaluation de la fonction diastolique régionale du ventricule gauche chez l'insuffisant coronarien.
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MeSH Terms
Coronary Artery Disease / physiopathology*,  ultrasonography*
Echocardiography, Doppler, Pulsed*
Middle Aged
Prospective Studies
Ventricular Function, Left*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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