| Pulse pressure is a predictor of vascular endothelial function in middle-aged subjects with no apparent heart disease. | |
| | |
MedLine Citation:
|
PMID: 20724375 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Elevated pulse pressure (PP) is increasingly being recognized as a cardiovascular risk factor. To investigate whether PP is associated with endothelial function in subjects with no apparent heart disease we prospectively assessed brachial flow-mediated dilation (FMD) in 525 consecutive subjects with no apparent heart disease [323 (61%) men, mean age 52 +/- 11 years, mean body mass index (BMI) 26 +/- 4 kg/m(2)]. Following an overnight fast and discontinuation of all medications for >/= 12 hours, the FMD and endothelium-independent, nitroglycerin-mediated vasodilation (NTG) were assessed using high-resolution linear array ultrasound. Univariate linear analysis revealed a significant inverse association between FMD and PP (r = -0.65, p < 0.01), systolic blood pressure (r = -0.52, p < 0.01) and age (r = -0.21, p < 0.05). Multivariate analysis showed that PP was the strongest independent predictor of FMD. We therefore divided the study population into two groups: group A (n = 290) </= the median PP, and group B (n = 235) > the median PP of 50 mmHg. Male sex, hypertension, diabetes, BMI, heart rate, and the use of aspirin, long-acting nitrates, calcium channel blockers, angiotensin-converting enzyme inhibitors and beta blockers were significantly more common in Group B compared with Group A. FMD but not NTG was significantly greater in patients with PP </= the median PP, compared with > the median PP (14.9 +/- 7.9% vs 10.8 +/- 8.8%, p < 0.001 and 16.1 +/- 9.6% vs 14.8 +/- 8.4%, p = 0.38; respectively). Thus, PP is inversely associated with brachial FMD in middle-aged subjects with no apparent heart disease, suggesting a potential mechanism whereby elevated PP contributes to cardiovascular disease. Long-term follow-up is warranted to elucidate the incidence of coronary artery disease in both study groups. |
| | |
Authors:
|
Roy Beigel; Danny Dvir; Yaron Arbel; Alon Shechter; Micha S Feinberg; Michael Shechter |
Related Documents
:
|
9605725 - Changes of circadian blood pressure patterns are associated with the occurence of lucun... 16443415 - Blood pressure usually considered normal is associated with an elevated risk of cardiov... 1071865 - The relative importance of the major risk factors in atherosclerotic and other diseases. 19232755 - Coronary heart disease benefits from blood pressure and lipid-lowering. 15275865 - Protection of lung tissue against ischemia/reperfusion injury by preconditioning with i... 1934325 - Amrinone during porcine intraperitoneal sepsis. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Vascular medicine (London, England) Volume: 15 ISSN: 1477-0377 ISO Abbreviation: Vasc Med Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-08-20 Completed Date: 2010-12-30 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9610930 Medline TA: Vasc Med Country: England |
Other Details:
|
Languages: eng Pagination: 299-305 Citation Subset: IM |
Affiliation:
|
Leviev Heart Center, Chaim Sheba Medical Center, Tel Hashomer, Israel, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Atherosclerosis / epidemiology, physiopathology Blood Pressure* Brachial Artery / physiology Coronary Artery Disease / epidemiology*, physiopathology Endothelium, Vascular / physiology* Female Humans Hypertension / epidemiology*, physiopathology Male Middle Aged Predictive Value of Tests Prognosis Risk Factors Vasodilation / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Influence of polyvascular disease on cardiovascular event rates. Insights from the REACH Registry.
Next Document: Delivery of negatively charged liposomes into the atheromas of Watanabe heritable hyperlipidemic rab...