Document Detail


Pulse pressure is an independent predictor for the progression of aortic wall calcification in patients with controlled hyperlipidemia.
MedLine Citation:
PMID:  14757775     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent epidemiological studies suggested that calcifications of the aorta and the coronary arteries are important predictors for cardiovascular morbidity and mortality. However, the relation between blood pressure components and the progression of vascular wall calcification has remained unclear. We quantified calcium deposits in the abdominal aorta as the percentage of aortic calcification volume (%ACV) using computed tomography in patients with hyperlipidemia. Those who had aortic calcification were treated with lipid-lowering agents and followed-up for >2 years (6.3+/-3.2 years). The relationship between the components of blood pressure and the increase in %ACV per year (Delta%ACV/year) was assessed in subjects in whom serum lipid levels were well controlled during the follow-up periods. An age- and sex-adjusted correlation analysis showed that Delta%ACV/year was significantly correlated to body mass index (r=0.229, P=0.015), systolic blood pressure (r=0.244, P=0.009), and pulse pressure (r=0.359, P<0.001). A multivariate regression analysis revealed that pulse pressure is an independent and the most sensitive predictor for Delta%ACV/year (beta=0.389, P<0.001) among the blood pressure components. These results suggested that increase in pulse pressure promotes the progression of vascular calcification.
Authors:
Yoshikazu Miwa; Motoo Tsushima; Hisatomi Arima; Yuhei Kawano; Toshiyuki Sasaguri
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-02-02
Journal Detail:
Title:  Hypertension     Volume:  43     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-02-27     Completed Date:  2004-05-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  536-40     Citation Subset:  IM    
Affiliation:
Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan. ymiwa@clipharm.med.kyushu-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Aortic Diseases / etiology*,  physiopathology,  radiography
Blood Pressure*
Calcinosis / etiology*,  physiopathology,  radiography
Disease Progression
Female
Follow-Up Studies
Humans
Hyperlipidemias / complications*,  drug therapy
Male
Middle Aged
Pulse
Risk Factors
Tomography, X-Ray Computed
Comments/Corrections
Comment In:
Hypertension. 2004 Mar;43(3):531-2   [PMID:  14744932 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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