Document Detail


Pulse pressure in youth and carotid intima-media thickness in adulthood: the cardiovascular risk in young Finns study.
MedLine Citation:
PMID:  19265060     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: Large pulse pressure associates with atherosclerosis, but it is unclear if it contributes to the development of atherosclerosis or if atherosclerosis leads to pulse pressure widening. We examined whether exposure to large pulse pressure in childhood predicts carotid artery intima-media thickness in adulthood. METHODS: Carotid intima-media thickness was measured in 2146 adults in the Cardiovascular Risk in Young Finns Study. These subjects have blood pressure data available dating back to their childhood (baseline in 1980, ages 3 to 18 years). RESULTS: Baseline pulse pressure measured in adolescence was significantly related to carotid intima-media thickness measured in adulthood 21 years later (r=0.123, P<0.0001). The relation remained significant (P=0.0029) in models adjusted for age, sex, adolescent mean arterial pressure, adult systolic pressure, adult pulse pressure, body mass index, smoking, physical activity, and carotid artery diameter. Each 10 mm Hg increment in pulse pressure was associated with a 0.008-mm (95% CI, 0.003 to 0.013 mm) increase in carotid intima-media thickness. CONCLUSIONS: Exposure to wide pulse pressure in adolescence may induce changes that contribute to carotid artery intima-media thickening.
Authors:
Olli T Raitakari; Markus Juonala; Leena Taittonen; Antti Jula; Tomi Laitinen; Mika Kähönen; Jorma S A Viikari
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-03-05
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  40     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-31     Completed Date:  2009-04-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1519-21     Citation Subset:  IM    
Affiliation:
Departments of Clinical Physiology, Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland. olli.raitakari@utu.fi
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Distribution
Blood Pressure*
Carotid Arteries / ultrasonography
Carotid Artery Diseases / epidemiology*,  physiopathology*,  ultrasonography
Child
Child, Preschool
Female
Finland / epidemiology
Humans
Male
Multivariate Analysis
Pulsatile Flow*
Risk Factors
Tunica Intima / ultrasonography
Tunica Media / ultrasonography
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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