| Pulse pressure and coronary atherosclerosis progression in postmenopausal women. | |
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MedLine Citation:
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PMID: 15545509 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pulse pressure, an index of large artery stiffness, has been associated with coronary events. However, mechanisms for this association remain unclear. In this study, we examined the relationship between pulse pressure and the progression of coronary atherosclerosis and the effects of hormone replacement therapy (HRT) on pulse pressure in postmenopausal women with angiographically confirmed coronary disease followed for 3.2 years in the Estrogen Replacement in Atherosclerosis (ERA) trial. In the ERA trial, 309 postmenopausal women (mean age 66+/-7 years) with coronary disease were randomized to estrogen, estrogen plus progestin, or placebo, and followed for 3.2 years. Ten standardized epicardial segments were measured for minimal diameter values at baseline and follow-up using quantitative coronary angiography. For this study, mixed-model analysis of covariance was used to: (1) test the association between pulse pressure and change in mean minimum diameter (MMD) adjusted for baseline MMD and (2) the effect of HRT on follow-up pulse pressure. After adjustment for potential confounders, there was a significant graded increase in progression of coronary stenosis with increasing quartiles of baseline pulse pressure (P test for trend=0.0001). The progression rate in women with the highest quartile of baseline pulse pressure was 5-fold higher than in women in the lowest quartile (P<0.01). In postmenopausal women with coronary disease, increased levels of baseline pulse pressure are associated with subsequent progression of coronary atherosclerosis in postmenopausal women. HRT had no detectable effect on pulse pressure. |
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Authors:
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Girish V Nair; David Waters; William Rogers; Glen J Kowalchuk; Thomas D Stuckey; David M Herrington |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. Date: 2004-11-15 |
Journal Detail:
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Title: Hypertension Volume: 45 ISSN: 1524-4563 ISO Abbreviation: Hypertension Publication Date: 2005 Jan |
Date Detail:
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Created Date: 2004-12-31 Completed Date: 2005-07-12 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: United States |
Other Details:
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Languages: eng Pagination: 53-7 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine/Cardiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Blood Pressure* / drug effects Coronary Angiography Coronary Artery Disease / epidemiology*, physiopathology, radiography Disease Progression Estrogen Replacement Therapy Estrogens, Conjugated (USP) / pharmacology Female Follow-Up Studies Hormone Replacement Therapy Humans Medroxyprogesterone Acetate / pharmacology Middle Aged Postmenopause* Single-Blind Method Vascular Resistance |
| Grant Support | |
ID/Acronym/Agency:
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HL 45488/HL/NHLBI NIH HHS; M01-07122//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Estrogens, Conjugated (USP); 71-58-9/Medroxyprogesterone Acetate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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