| Pulse pressure and cardiovascular autonomic neuropathy according to duration of type 1 diabetes. | |
| | |
MedLine Citation:
|
PMID: 19437445 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: To evaluate changes in pulse pressure (PP) and markers of cardiovascular autonomic neuropathy (CAN) according to duration of type 1 diabetes mellitus (T1DM). METHODS: This cross-sectional controlled study evaluated 159 diabetic patients during a 3-min posture test (standing-squatting-standing) with continuous measurement of systolic (SBP), diastolic (DBP) and mean (MBP) blood pressure by a Finapres device. Arterial stiffness was indirectly assessed by PP and the slope of PP as a function of MBP calculated during the whole 3-min test. CAN was assessed by the expiration/inspiration pulse interval ratio (E/I R-R ratio) during deep breathing and by three indices measured during the squatting test. Patients were divided into four groups according to diabetes duration (<10 years, 11-20 years, 21-30 years and > 30 years from group 1 to group 4, respectively) and compared with age-matched non-diabetic subjects. RESULTS: PP progressively increased (p < 0.0001) and PP/MBP decreased (p < 0.0005) according to T1DM duration, whereas these parameters remained almost unchanged in age-matched control subjects. E/I ratio (p < 0.0001) and baroreflex gain (p < 0.0005) progressively decreased with T1DM duration. The parasympathetic index (squatting test vagal ratio-SqTv) significantly increased (p < 0.0001), whereas the sympathetic index (squatting test sympathetic ratio-SqTs) only tended to decrease (p = 0.12) according to diabetes duration. No such changes in CAN indices were observed in the non-diabetic population. CONCLUSIONS: PP increased according to T1DM duration in an age range where PP remained almost stable in controls, in agreement with accelerated arterial stiffening due to chronic hyperglycaemia. The baroreflex gain decreased and other indices of CAN also deteriorated with diabetes duration, more so indices reflecting parasympathetic rather than sympathetic dysfunction. |
| | |
Authors:
|
J C Philips; M Marchand; A J Scheen |
Related Documents
:
|
7143815 - Coma preceded by severe dysphagia in type ii diabetes mellitus. 9736135 - Autonomic functions in restrictive cardiomyopathy and constrictive pericarditis: a comp... 2074445 - Quantitation of skin vasomotor control in normal subjects and in diabetic patients with... 9466135 - Corrected qt interval in relation to the severity of diabetic autonomic neuropathy. 7077355 - Myelin sheath thickness and internodal length of nerve fibres in the developing feline ... 15461745 - Use of insulin and oral hypoglycemic medications in patients with diabetes mellitus and... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Diabetes/metabolism research and reviews Volume: 25 ISSN: 1520-7560 ISO Abbreviation: Diabetes Metab. Res. Rev. Publication Date: 2009 Jul |
Date Detail:
|
Created Date: 2009-07-06 Completed Date: 2009-11-02 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100883450 Medline TA: Diabetes Metab Res Rev Country: England |
Other Details:
|
Languages: eng Pagination: 442-51 Citation Subset: IM |
Affiliation:
|
Division of Diabetes, Nutrition and Metabolic Disorders, Department of Medicine, CHU Sart Tilman, Liège, Belgium. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Analysis of Variance Arteriosclerosis / complications, physiopathology Autonomic Nervous System / physiology, physiopathology* Blood Pressure / physiology* Cardiovascular Diseases / diagnosis, physiopathology Cardiovascular System / innervation, physiopathology Case-Control Studies Cross-Sectional Studies Diabetes Mellitus, Type 1 / complications, physiopathology* Diabetic Angiopathies / diagnosis, physiopathology* Diabetic Neuropathies / diagnosis, physiopathology* Female Humans Male Middle Aged Reference Values Time Factors Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Diastereochemical differentiation of bicyclic diols using metal complexation and collision-induced d...
Next Document: Negative ion fragmentations of deprotonated peptides containing post-translational modifications: di...