| Pulse pressure and aortic pulse wave are markers of cardiovascular risk in hypertensive populations. | |
| | |
MedLine Citation:
|
PMID: 11243313 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Pulse pressure (PP) and aortic pulse wave velocity (PWV) are significant markers of cardiovascular risk, but a similar role for central wave reflections has never been investigated. PROCEDURES: To determine the factors influencing PP, PWV, and carotid wave reflections, a cohort of 1087 patients with essential hypertension either treated or untreated was studied cross-sectionally. Atherosclerotic alterations (AA) were defined on the basis of clinical events and PWV evaluated from an automatic device. The carotid amplification index (CAI), a quantitative estimation of the magnitude of central wave reflections, was measured noninvasively from pulse wave analysis using radial and carotid aplanation tonometry. RESULTS: In the overall population, age and mean arterial pressure represented 30.4%, 32.3%, and 5.6% of the variance of, respectively PP, PWV, and CAI. For the latter, body weight and heart rate represented 22.9% of variability. On the basis of logistic regression, AA were associated, in addition to age, plasma creatinine and HDL cholesterol levels, and tobacco consumption to three mechanical factors, increased PP, increased PWV, and low diastolic blood pressure, but not by CAI (adjusted odds ratio: 1.00; 95% confidence intervals: 0.99-1.01). CONCLUSION: In cross-sectional hypertensive populations, PP and PWV, but not CAI, are significantly and independently associated with cardiovascular amplications. |
| | |
Authors:
|
R Asmar; A Rudnichi; J Blacher; G M London; M E Safar |
Related Documents
:
|
16110203 - Qualification of arterial stiffness as a risk factor to the progression of chronic kidn... 15005303 - Determination of radial artery compliance can increase the diagnostic power of pulse wa... 3886303 - The effect of tiaprofenic acid on blood pressure control in treated hypertensive patients. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: American journal of hypertension Volume: 14 ISSN: 0895-7061 ISO Abbreviation: Am. J. Hypertens. Publication Date: 2001 Feb |
Date Detail:
|
Created Date: 2001-03-12 Completed Date: 2001-04-19 Revised Date: 2009-02-24 |
Medline Journal Info:
|
Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: United States |
Other Details:
|
Languages: eng Pagination: 91-7 Citation Subset: IM |
Affiliation:
|
L'institut CardioVasculaire, Paris, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Aorta / physiopathology* Blood Pressure* Cardiovascular Diseases / etiology* Carotid Arteries / physiopathology Cohort Studies Cross-Sectional Studies Diastole Female Humans Hypertension / complications*, physiopathology* Male Middle Aged Pulse* Risk Factors |
| Comments/Corrections | |
Comment In:
|
Am J Hypertens. 2001 Feb;14(2):183-5
[PMID:
11243311
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Left ventricular hypertrophy and angiotensin II antagonists.
Next Document: A systematic review of predictors of maintenance of normotension after withdrawal of antihypertensiv...