Document Detail

Pulse pressure amplification in relation to body fatness.
MedLine Citation:
PMID:  22008022     Owner:  NLM     Status:  MEDLINE    
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT: Aortic-brachial pulse pressure amplification (PPA) is a measure of arterial elasticity and it is also an independent cardiovascular risk factor. The PPA is mainly determined by age, height, central and peripheral pressure waveforms characteristics, including measures of arterial stiffness and wave reflection.
WHAT THIS STUDY ADDS: In this study, however, we demonstrate that PPA is also significantly associated with indirect indices of body fatness. As the body fatness is treatable, our findings might be used as a reference for future studies on the effects of body fat reduction on PPA and the PPA-related cardiovascular risk. AIMS Arterial pressure transfer to the periphery is accompanied by pulse pressure amplification (PPA). Pulse pressure is influence by body fat. The purpose of the present study was to evaluate any possible inter-relation between body fatness and PPA in healthy subjects.
METHODS: Haemodynamic and wave reflection indices were estimated by pulse wave analysis. Body fat was measured by bio-impedance.
RESULTS: A total of 367 healthy volunteers (136 men and 231 women) was studied. Pulse pressure amplification correlated significantly with percentage of body fat (r=-0.53, P < 0.0001), age (r=-0.62, P < 0.0001), height (r= 0.43, P < 0.0001), heart rate (r= 0.28, P < 0.0001) and mean blood pressure (r=-0.29, P < 0.0001). The association of PPA with body fat was also significant in a multiple linear regression model. Age was an independent predictor of PPA and analysis of study subjects subdivided into two groups, those <50 years and those >50 years showed that body fatness correlated inversely and significantly with PPA in individuals both younger and older than 50 years (r=-0.44, P < 0.0001, r=-0.37, P < 0.0001 respectively). Augmentation pressure was also associated significantly with percentage of body fat in both subgroups (r= 0.48, P < 0.0001 and r= 0.49, P < 0.0001 respectively).
CONCLUSIONS: This study performed on healthy subjects showed that pulse pressure amplification is related to body fatness over a wide age range. Percentage body fat is significantly associated with augmentation pressure, a component of central pulse pressure.
Andrzej Wykretowicz; Agnieszka Rutkowska; Tomasz Krauze; Dagmara Przymuszala; Przemyslaw Guzik; Ryszard Marciniak; Henryk Wysocki
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  73     ISSN:  1365-2125     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-13     Completed Date:  2012-06-28     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  546-52     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors. British Journal of Clinical Pharmacology © 2011 The British Pharmacological Society.
Department of Internal Medicine, Division of Cardiology-Intensive Therapy Department of General, Gastroenterological and Endocrinological Surgery, University School of Medicine, 49 Przybyszewskiego, Poznan, Poland.
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MeSH Terms
Adipose Tissue / metabolism*
Aged, 80 and over
Blood Flow Velocity / physiology
Blood Pressure / physiology*
Heart Rate / physiology*
Middle Aged
Models, Biological
Pulsatile Flow / physiology*
Regression Analysis
Vascular Resistance / physiology
Young Adult

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