Document Detail

Pulse pressure amplification, adiposity and metabolic syndrome in subjects under chronic antihypertensive therapy: the role of heart rate.
MedLine Citation:
PMID:  17988669     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Body mass index (BMI) and waist circumference (WC) are increased in subjects chronically treated for hypertension. However, the relationships of BMI, WC and metabolic syndrome (MS) with central wave reflections and pulse pressure (PP) amplification have never been investigated. METHODS: A cohort of 517 treated hypertensives was studied cross-sectionally as function of BMI, WC and presence of MS, the latter used as index of insulin resistance. In men and women, carotid wave reflections were evaluated using pulse wave analysis and augmentation index measurement. PP amplification between brachial and carotid arteries was determined as a vascular factor contributing to protect against an increased afterload. RESULTS: When compared to their own controls, treated hypertensive subjects with increased BMI, WC or MS did not differ in terms of mean values of brachial and carotid blood pressure and augmentation index. However, they were characterized by increased heart rate (HR) and PP amplification. Such results were independent of age, drug treatment, and traditional cardiovascular risk factors. After HR adjustment, the increased PP amplification observed in subjects with high WC or MS became non-significant in men, but remained unmodified in women. The presence of beta-blockade did not modify the result. CONCLUSION: In treated hypertensive subjects, adiposity and insulin sensitivity influence independently PP amplification. The finding is observed mainly in women.
Anne Claire Vergnaud; Athanase D Protogerou; Yan Li; Sébastien Czernichow; Claire Vesin; Jacques Blacher; Michel E Safar
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Publication Detail:
Type:  Journal Article     Date:  2007-11-07
Journal Detail:
Title:  Atherosclerosis     Volume:  199     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-24     Completed Date:  2008-08-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  222-9     Citation Subset:  IM    
INSERM U557, INRA U1125CNAM EA3200, Iniv Paris 13, CRNH IdF, Bobigny, F-93017 France.
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MeSH Terms
Adipose Tissue / physiology
Antihypertensive Agents / therapeutic use*
Blood Pressure / physiology*
Body Mass Index
Brachial Artery / physiology
Carotid Arteries / physiology
Cross-Sectional Studies
Heart Rate / physiology*
Hypertension / drug therapy,  epidemiology*,  physiopathology*
Insulin Resistance
Metabolic Syndrome X / epidemiology*,  physiopathology*
Middle Aged
Risk Factors
Sex Distribution
Reg. No./Substance:
0/Antihypertensive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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