Document Detail

Pulse oximetry saturation to fraction inspired oxygen ratio as a measure of hypoxia under general anesthesia and the influence of positive end-expiratory pressure.
MedLine Citation:
PMID:  20655696     Owner:  NLM     Status:  MEDLINE    
PURPOSE: In ICU patients with acute lung injury, the pulse oximetry saturation (Spo(2)) to fraction of inspired oxygen (Fio(2)) (S/F) ratio is a reliable surrogate measure for the P/F (Pao(2)/Fio(2)) ratio. Our goal was to determine the correlation of the S/F to the P/F in a large sample of patients undergoing general anesthesia and the influence of positive end-expiratory pressure (PEEP) on this measure.
METHODS: We studied adult general anesthetics performed with arterial blood gas analysis. Intraoperative data were collected from an anesthesia information system. The S/F ratios corresponding to P/F ratios of 300 were determined.
RESULTS: A total of 4439 values were collected. Linear correlation between S/F and P/F was identified (r = 0.46; P < .01) with a P/F of 300 corresponding to an S/F of 206. The correlation was stronger in patients with 5 to 9 cm PEEP (r = 0.52; P < .01), more than 9 cm H(2)O PEEP (r = 0.68; P < .01), and a P/F ratio of 300 or less (r = 0.61; P < .01).
CONCLUSION: The S/F correlates with the P/F in our cohort of patients undergoing general anesthesia, especially those ventilated with PEEP more than 9 cm H(2)O and/or with P/F less than 300. It has use as a noninvasive measure to screen for increased pulmonary dysfunction and to trend oxygenation during a general anesthetic.
Ravi S Tripathi; James M Blum; Andrew L Rosenberg; Kevin K Tremper
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Publication Detail:
Type:  Journal Article     Date:  2010-07-23
Journal Detail:
Title:  Journal of critical care     Volume:  25     ISSN:  1557-8615     ISO Abbreviation:  J Crit Care     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-14     Completed Date:  2010-12-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610642     Medline TA:  J Crit Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  542.e9-13     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Department of Anesthesiology, University of Michigan Health System, Ann Arbor, MI 48109, USA.
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MeSH Terms
Aged, 80 and over
Anesthesia, General
Anoxia / diagnosis*
Middle Aged
Monitoring, Intraoperative*
Oximetry / methods*
Oxygen / blood*
Positive-Pressure Respiration
Reproducibility of Results
Young Adult
Reg. No./Substance:

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