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Pulse methylprednisolone therapy for the treatment of extensive alopecia areata.
MedLine Citation:
PMID:  23336179     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Background: Since the mainstay of pathogenesis depends on autoimmune process, systemic steroids are widely used in the treatment of alopecia with various side effects. To avoid side effects of long term steroid treatment, pulse methylprednisolone therapy appear to be a safe treatment option. Objective: To determine effect of pulse methylprednisolone therapy for the treatment of adult alopecia areata. Methods: Demographic features of all patients were recorded before the treatment. Patients received methylprednisolone 500 mg intravenously in 3 consecutive days by monthly for 3 months. Patients were followed up for 3 months. Treatment responses were defined by complete regrowth (100%), significant regrowth (more than 50%) and minimal regrowth (less than 50%). Results: Totally 15 patients were enrolled in this study. In the end of the study we observed two patients had significant regrowth and one patient had minimal regrowth in multifocal alopecia areata (n=4); one patient had significant regrowth and one patient had minimal regrowth in alopecia universalis (n=8); three patients had no regrowth in alopecia totalis(n=3). Conlusions: Our study suggests that pulse methylprednisolone therapy might be a therapeutic option for severe multifocal alopecia areata. But in alopecia totalis or universalis treatment results are unsatisfactory.
Authors:
Gürol Açikgöz; Ibrahim Ozmen; Mutlu Cayirli; Y1ld1ray Yeniay; Osman Köse
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-22
Journal Detail:
Title:  The Journal of dermatological treatment     Volume:  -     ISSN:  1471-1753     ISO Abbreviation:  J Dermatolog Treat     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8918133     Medline TA:  J Dermatolog Treat     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Gulhane School of Medicine, Dermatology, GATA Dermatoloji AD Etlik, Ankara, Turkey, 06018, +903123044459, +903123044450.
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