| Pulse methylprednisolone therapy for the treatment of extensive alopecia areata. | |
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MedLine Citation:
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PMID: 23336179 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract Background: Since the mainstay of pathogenesis depends on autoimmune process, systemic steroids are widely used in the treatment of alopecia with various side effects. To avoid side effects of long term steroid treatment, pulse methylprednisolone therapy appear to be a safe treatment option. Objective: To determine effect of pulse methylprednisolone therapy for the treatment of adult alopecia areata. Methods: Demographic features of all patients were recorded before the treatment. Patients received methylprednisolone 500 mg intravenously in 3 consecutive days by monthly for 3 months. Patients were followed up for 3 months. Treatment responses were defined by complete regrowth (100%), significant regrowth (more than 50%) and minimal regrowth (less than 50%). Results: Totally 15 patients were enrolled in this study. In the end of the study we observed two patients had significant regrowth and one patient had minimal regrowth in multifocal alopecia areata (n=4); one patient had significant regrowth and one patient had minimal regrowth in alopecia universalis (n=8); three patients had no regrowth in alopecia totalis(n=3). Conlusions: Our study suggests that pulse methylprednisolone therapy might be a therapeutic option for severe multifocal alopecia areata. But in alopecia totalis or universalis treatment results are unsatisfactory. |
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Authors:
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Gürol Açikgöz; Ibrahim Ozmen; Mutlu Cayirli; Y1ld1ray Yeniay; Osman Köse |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-22 |
Journal Detail:
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Title: The Journal of dermatological treatment Volume: - ISSN: 1471-1753 ISO Abbreviation: J Dermatolog Treat Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8918133 Medline TA: J Dermatolog Treat Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Gulhane School of Medicine, Dermatology, GATA Dermatoloji AD Etlik, Ankara, Turkey, 06018, +903123044459, +903123044450. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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