| Pulse pressure and arterial compliance prior to pregnancy and the development of complicated hypertension during pregnancy. | |
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MedLine Citation:
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PMID: 20639475 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined the relationship between prepregnant pulse pressure (PP), mean arterial pressure (MAP), cardiac output (CO)/PP, a measure of arterial compliance, and development of complicated hypertension (CH) during pregnancy with the goal of identifying a potential predictor of CH. Twenty nulliparous participants were studied before pregnancy; 17 had normal pregnancies (control; CTL) and 3 CH. Blood pressure monitoring was performed using tonometry. Cardiac output was determined by Doppler echocardiograph. Data are expressed as mean +/- SD. Prepregnant PP was significantly higher in CH participants (CH: 58.3 +/- 6.3, CTL: 46.2 +/- 1.7 mm Hg; P = .02). Cardiac output /pulse pressure was significantly lower in CH participants (CH: 6.9 +/- 1.8, CTL: 10.6 +/- 2.8; P = .04). Mean arterial pressure was not significantly different. Increased PP before pregnancy may suggest increased risk for CH. With accurate prediction of CH before pregnancy, initiation of preventative measures could begin earlier, either prior to or in early pregnancy, potentially increasing preventative efficacy and decreasing CH. |
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Authors:
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Sarah Hale; Martha Choate; Adrienne Schonberg; Robert Shapiro; Gary Badger; Ira M Bernstein |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-07-16 |
Journal Detail:
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Title: Reproductive sciences (Thousand Oaks, Calif.) Volume: 17 ISSN: 1933-7205 ISO Abbreviation: Reprod Sci Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-11 Completed Date: 2010-11-22 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 101291249 Medline TA: Reprod Sci Country: United States |
Other Details:
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Languages: eng Pagination: 871-7 Citation Subset: IM |
Affiliation:
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Department of Obstetrics, Gynecology and Reproductive Sciences, University of Vermont, Burlington, VT 05405, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Arteries / physiopathology* Biological Markers / blood Blood Pressure* Cardiac Output Case-Control Studies Catecholamines / blood Compliance Echocardiography, Doppler Female Humans Hypertension, Pregnancy-Induced / blood, etiology*, physiopathology Manometry Parity Pre-Eclampsia / etiology, physiopathology Pregnancy Risk Assessment Risk Factors Vermont Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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HL 71944/HL/NHLBI NIH HHS; M01 RR109/RR/NCRR NIH HHS; R01 HL071944-07/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Catecholamines |
| Comments/Corrections | |
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