Document Detail

Pulse Arrival Time as surrogate for systolic blood pressure changes during impending neurally mediated syncope.
MedLine Citation:
PMID:  23366874     Owner:  NLM     Status:  MEDLINE    
Blood pressure regulation failures cause neurally mediated syncope often resulting in a fall. A warning device might help to make patients aware of an impending critical event or even trigger the patient to perform countermeasures such as lying down or isometric exercises. We previously demonstrated that the Pulse Arrival Time (PAT) methodology is a potential approach to enable early detection of impending faints. The aim of the present study was to evaluate whether PAT can be used as an easy to measure beat-to-beat surrogate for systolic blood pressure (SBP) changes during a passive standing exercise (head-up tilt table testing (HUTT)). A significant PAT increase of more than 10 % was accompanied with a critical SBP decrease in syncope patients. Although PAT is in general not considered as a good measure of absolute blood pressure we found strong correlations (R>0.89, P<0.01) of SBP and PAT after PAT began to increase. Therefore, our data suggest that the pulse arrival time is useful to monitor blood pressure changes in patients with neurally mediated syncope. This might open up new avenues to prevent falls in these patients.
Jens Muehlsteff; Anita Ritz; Thomas Drexel; Christian Eickholt; Paulo Carvalho; Ricardo Couceiro; Malte Kelm; Christian Meyer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference     Volume:  2012     ISSN:  1557-170X     ISO Abbreviation:  Conf Proc IEEE Eng Med Biol Soc     Publication Date:  2012  
Date Detail:
Created Date:  2013-01-31     Completed Date:  2013-08-02     Revised Date:  2014-08-21    
Medline Journal Info:
Nlm Unique ID:  101243413     Medline TA:  Conf Proc IEEE Eng Med Biol Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4283-6     Citation Subset:  IM    
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MeSH Terms
Blood Pressure Determination / methods*
Diagnosis, Computer-Assisted / methods*
Heart Rate
Middle Aged
Pulse Wave Analysis / methods*
Reproducibility of Results
Sensitivity and Specificity
Syncope / diagnosis*,  physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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