Document Detail

Pulsatile vs. mean component of baroreflex compensation for posthemorrhage hypotension.
MedLine Citation:
PMID:  3381895     Owner:  NLM     Status:  MEDLINE    
We studied the influence of pulsatile pressure and mean arterial pressure signals on the restoration of arterial pressure after 10% hemorrhage in seven anesthetized dogs. After transection of the aortic nerve, a quick 10% hemorrhage was repeated under four different sinus conditions: condition 1, carotid sinus pressure depulsated and fixed at a level equal to the prehemorrhage level (no feedback); condition 2, pulsatile component of aortic pressure fed back to the carotid sinus with a fixed mean pressure (pulsatile feedback); condition 3, depulsated mean aortic pressure fed back (mean pressure feedback); condition 4, both pulsatile and mean pressure fed back (pulsatile plus mean component feedback). The restoration of arterial pressure in condition 2 was not significantly different from that in condition 1, but there was greater restoration in conditions 3 and 4. At 1.5 min posthemorrhage, the open-loop gains calculated from the restoration values were nearly zero for the pulsatile feedback only, 2.8 +/- 0.8 for mean arterial pressure feedback, and 1.5 +/- 0.3 for pulsatile and mean pressure feedback. These results indicate that the pulsatile component of the carotid baroreflex contributes minimally to the restoration of arterial pressure after 10% hemorrhage in the anesthetized dog.
T Yamazaki; M J Brunner; K Sagawa
Related Documents :
8205295 - Midas: rationale, design and descriptive data of trial patients. the midas research group.
1566935 - Carotid chemoreceptors influence arterial pressure in intact and aortic-denervated rats.
1621435 - Retinal duplex scanning in cerebrovascular disease and hypertension.
1409735 - Inhibition by cocaine of the baroreflex in the rat.
23910125 - Decompression of thoracic duct: new approach for the treatment of failing fontan.
9562195 - Gas exchange and lung mechanics during percutaneous transtracheal ventilation in an unp...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  254     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1988 Jun 
Date Detail:
Created Date:  1988-07-15     Completed Date:  1988-07-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H1074-80     Citation Subset:  IM    
Department of Biomedical Engineering, Johns Hopkins Medical School, Baltimore, Maryland 21205.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Pressure*
Blood Transfusion
Heart Rate
Hemorrhage / physiopathology*
Hypotension / etiology,  physiopathology*
Models, Biological
Pressoreceptors / physiology*
Reference Values
Time Factors
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Functional consequences of acute anterior vs. posterior wall ischemia in canine left ventricles.
Next Document:  Albumin improves stability and longevity of perfluorochemical-perfused hearts.