Document Detail

Pulsatile oxytocin administered to ewes at 120 to 140 days gestational age increases the rate of maturation of the fetal electrocorticogram and nuchal activity.
MedLine Citation:
PMID:  1401779     Owner:  NLM     Status:  MEDLINE    
Spontaneous, long lasting epochs of myometrial contractility, contractures, occur throughout the majority of pregnancy in sheep. Contractures are temporally related to a switch in fetal electroencephalogram (ECoG) patterns from low to high voltage. In late gestation, fetal ECoG increases in voltage. We have previously suggested that contractures may influence fetal ECoG maturation. In the present study, we hypothesized that a sustained increase in the frequency of myometrial contractures in pregnant sheep at 120-140 days gestation would accelerate maturation of the fetal ECoG. Five pregnant ewes were pulsed with oxytocin 600 intravenously for five minutes in every 30 minutes from 127.8 +/- 1.5 days gestational age for a minimum of six days. Six control ewes received pulses of saline. Fetuses of all eleven ewes were instrumented with bilateral electrodes to record fetal ECoG and nuchal muscle activity. Fetal high voltage (HV) ECoG increased in amplitude in both groups but the rate of increase was faster in the fetuses of ewes receiving oxytocin. There were no differences between the two groups in the duration of HV ECoG. The percentage increase in the amount of time the fetal nuchal muscles were active compared with the baseline day before infusion was only significant in the oxytocin infused group on the first day of oxytocin infusion. These findings support the hypothesis that myometrial activity during pregnancy has the capacity to influence fetal neural development.
D W Sadowsky; J K Martel; S L Jenkins; M G Poore; T Cabalum; P W Nathanielsz
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of developmental physiology     Volume:  17     ISSN:  0141-9846     ISO Abbreviation:  J. Dev. Physiol.     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-11-17     Completed Date:  1992-11-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7910737     Medline TA:  J Dev Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  175-81     Citation Subset:  IM    
Laboratory for Pregnancy and Newborn Research, Cornell University, Ithaca, New York 14853.
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MeSH Terms
Drug Administration Schedule
Fetal Heart / drug effects,  physiology*
Fetus / physiology*
Gases / blood
Gestational Age*
Myometrium / drug effects,  physiology
Neck Muscles / drug effects,  physiology*
Oxytocin / administration & dosage*,  pharmacology
Pulsatile Flow
Reg. No./Substance:
0/Gases; 50-56-6/Oxytocin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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