| Pulsatile administration of gonadotrophin releasing hormone and oral administration of naltrexone in hypothalamic amenorrhoea. | |
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MedLine Citation:
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PMID: 8276957 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Between 1979 and 1990, 73 patients suffering from hypothalamic amenorrhoea were treated by pulsatile administration of gonadotrophin releasing hormone (GnRH) in 359 treatment cycles. Seventy-two pregnancies were achieved. In 64 favourable patients in whom hypothalamic amenorrhoea constituted the only reason for infertility, a pregnancy rate of 29% per cycle could be obtained. Patients who conceived during pulsatile GnRH required an average of only 2.4 cycles per conception. Twelve out of 24 patients with hypothalamic amenorrhoea who exhibited an ovulatory response to pulsatile GnRH, ovulated during oral administration of naltrexone; such responsiveness to opioid antagonism was, however, restricted to the less serious grades. In conclusion, pulsatile administration of GnRH continues to be a highly effective mode of treatment of infertility due to hypothalamic amenorrhoea of various aetiologies. A subgroup of these patients may be successfully treated by the oral administration of naltrexone. |
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Authors:
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G Leyendecker; S Waibel-Treber; L Wildt |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Human reproduction (Oxford, England) Volume: 8 Suppl 2 ISSN: 0268-1161 ISO Abbreviation: Hum. Reprod. Publication Date: 1993 Nov |
Date Detail:
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Created Date: 1994-02-10 Completed Date: 1994-02-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8701199 Medline TA: Hum Reprod Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 184-8 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynaecology, Academic Teaching Hospital, University of Frankfurt, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amenorrhea
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drug therapy*,
etiology,
physiopathology Female Gonadotropin-Releasing Hormone / administration & dosage*, therapeutic use Humans Hypothalamic Diseases / complications* Infertility, Female / drug therapy, etiology Naltrexone / administration & dosage*, therapeutic use Ovulation Periodicity Pregnancy |
| Chemical | |
Reg. No./Substance:
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16590-41-3/Naltrexone; 33515-09-2/Gonadotropin-Releasing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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