Document Detail

Pulsatile administration of Gn-RH in hypothalamic amenorrhea.
MedLine Citation:
PMID:  6377637     Owner:  NLM     Status:  MEDLINE    
The physiological and pathophysiological basis of hypothalamic amenorrhoea are reviewed as well as the clinical results of chronic intermittent (pulsatile) administration of Gn-RH in the treatment of infertility. Hypothalamic amenorrhoea is considered to be the result of a deficient hypothalamic secretion of Gn-RH. By pulsatile administration of Gn-RH, which is a pre-requisite of normal pituitary gonadotrophic function, deficient endogenous Gn-RH is replaced. If an adequate dose of Gn-RH is provided, which takes into account the degree of impairment of hypothalamic function in the individual case, follicular maturation, ovulation and corpus luteum formation are achieved in nearly every treatment cycle. Although dependent also on factors other than the treated dysfunction, a high conception rate is achieved.
G Leyendecker; L Wildt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Upsala journal of medical sciences     Volume:  89     ISSN:  0300-9734     ISO Abbreviation:  Ups. J. Med. Sci.     Publication Date:  1984  
Date Detail:
Created Date:  1984-08-03     Completed Date:  1984-08-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0332203     Medline TA:  Ups J Med Sci     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  19-32     Citation Subset:  IM    
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MeSH Terms
Amenorrhea / complications,  drug therapy*,  physiopathology
Dose-Response Relationship, Drug
Gonadotropins / secretion
Hormones / therapeutic use
Hypothalamus / physiopathology*
Infertility, Female / drug therapy,  etiology
Infusions, Parenteral
Luteal Phase / drug effects
Ovulation / drug effects
Pituitary Hormone-Releasing Hormones / administration & dosage*
Reg. No./Substance:
0/Gonadotropins; 0/Hormones; 0/Pituitary Hormone-Releasing Hormones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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