Document Detail

Pulmono-atrial shunt and lung assist to treat right ventricular failure.
MedLine Citation:
PMID:  21622180     Owner:  NLM     Status:  MEDLINE    
In right ventricular failure (RVF) a decrease of right ventricular afterload and improvement of left atrial filling could be achieved by a pulmonary artery-left atrial (PA)-shunt. To avoid cyanosis, artificial oxygenation is necessary. In 11 pigs a PA-shunt was created. An interventional lung assist device (ILA) was installed from the femoral artery to vein in 5 pigs (serial in relation to native lung: Group I) and into the PA-shunt in 6 pigs (parallel: Group II). RVF was induced by pulmonary artery banding. Right ventricular performance was determined by pulse contour analysis, pressure - and flow measurements. In both groups a stable RVF was generated. In Group I cardiac output trended to increase but neither right ventricular filling pressures nor arterial pressure changed significantly. The PaO2 decreased significantly. In Group II cardiac output and arterial pressure increased significantly under a shunt flow of 2.3- 2.6 l/min and the animals recovered from cardiogenic shock. In conclusion a PA-shunt with a parallel lung assist can effectively reverse the deleterious effects of RVF.
Jan Spillner; Andrea Amerini; Nima Hatam; Steffen Rex; Frank Pott; Andreas Goetzenich; Ares Menon; Thorsten Repas; Frederik Steiner; Rüdiger Autschbach; Angelo Carpi; Oliver Oster
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-06-01
Journal Detail:
Title:  Frontiers in bioscience (Landmark edition)     Volume:  16     ISSN:  1093-4715     ISO Abbreviation:  Front Biosci (Landmark Ed)     Publication Date:  2011  
Date Detail:
Created Date:  2011-05-30     Completed Date:  2011-10-03     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  101612996     Medline TA:  Front Biosci (Landmark Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2342-51     Citation Subset:  IM    
Clinic for Cardiothoracic Surgery, University Hospital RWTH Aachen, Pauwelsstr. 30, D-52074 Aachen, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Artificial Organs
Blood Pressure
Cardiac Output
Cardiac Surgical Procedures / methods*
Disease Models, Animal
Heart Atria / surgery
Heart Failure / surgery
Heart-Assist Devices
Lung / surgery
Pulmonary Artery / surgery
Pulmonary Gas Exchange
Sus scrofa
Ventricular Dysfunction, Right / physiopathology,  surgery*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Role of purinergic signalling in neuro-immune cells and adult neural progenitors.
Next Document:  The role of Wnt in cell signaling and cell adhesion during early vertebrate development.