| Pulmonary ventilatory function decreases in proportion to increasing altitude. | |
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MedLine Citation:
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PMID: 11990165 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this study was to examine how pulmonary ventilatory function, including response to bronchodilation, is related to altitude during high-altitude trekking. This cohort experiment consisted of multiple spirometric tests before and after bronchodilation in participants at baseline (1624 m) and at different altitudes (3404-4896 m) during a 2-week trek. The setting was in the Himalayas. Eleven men (ages 22-68 years) and eight women (ages 19-42 years) participated. Interventions were at altitudes of 1624 m to 5265 m; albuterol was administered via Rotahaler. Forced vital capacity (FVC) decreased by an average of 3.8% [95% confidence interval (CI) 1.6 to 6.0] per 1000-m altitude increment. Forced expiratory volume in 1 second (FEV1.0) decreased 3.7% (95% CI 1.9 to 5.5) per each 1000-m altitude increment. Maximal midexpiratory flow rate (FEF25-75%) decreased by 3.6% (95% CI 0.9 to 6.3) per each 1000-m altitude increment. Small, postalbuterol flow increases were present at baseline and at altitude. Ventilatory function returned quickly toward baseline upon descent. One trekker developed cough, dyspnea at rest, extreme weakness, rales, tachycardia, and oxygen desaturation to 71%. His ventilatory measurements did not differ significantly (p > 0.32) from the group means. We concluded that changes in some pulmonary ventilatory parameters (FVC, FEV1.0, and FEF25-75%) were proportional to the magnitude of altitude during a high-altitude trek. These were tolerated well and do not seem to relate to acute mountain sickness. A bronchodilator effect was not increased at altitude. |
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Authors:
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F Hashimoto; B McWilliams; C Qualls |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Wilderness & environmental medicine Volume: 8 ISSN: 1080-6032 ISO Abbreviation: Wilderness Environ Med Publication Date: 1997 Nov |
Date Detail:
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Created Date: 2002-05-06 Completed Date: 2002-06-04 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9505185 Medline TA: Wilderness Environ Med Country: United States |
Other Details:
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Languages: eng Pagination: 214-7 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of New Mexico School of Medicine, Albuquerque 87131, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Albuterol / pharmacology Altitude* Altitude Sickness / physiopathology* Bronchodilator Agents / pharmacology Cohort Studies Female Forced Expiratory Volume / drug effects, physiology Humans Male Middle Aged Mountaineering / physiology Pulmonary Ventilation / drug effects, physiology* Spirometry |
| Grant Support | |
ID/Acronym/Agency:
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M01 RR-00997/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Bronchodilator Agents; 18559-94-9/Albuterol |
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