Document Detail

Pulmonary veno-occlusive disease presenting with recurrent pulmonary oedema and the use of nitric oxide to predict response to sildenafil.
MedLine Citation:
PMID:  18820120     Owner:  NLM     Status:  MEDLINE    
Pulmonary veno-occlusive disease (PVOD) is a disorder which causes progressive pulmonary hypertension, usually presenting with worsening dyspnoea and right heart failure. Pulmonary oedema induced by pulmonary vasodilator therapy to reduce pulmonary arterial pressure has been well described in PVOD, but here we describe a case of PVOD presenting with recurrent episodes of acute non-cardiogenic pulmonary oedema, in the absence of significant pulmonary hypertension. Concern over the risk of precipitating pulmonary oedema led us to use inhaled nitric oxide to predict the safety and efficacy of sildenafil.
B C Creagh-Brown; A G Nicholson; R Showkathali; J S R Gibbs; L S G E Howard
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Thorax     Volume:  63     ISSN:  1468-3296     ISO Abbreviation:  Thorax     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-29     Completed Date:  2008-10-27     Revised Date:  2009-01-22    
Medline Journal Info:
Nlm Unique ID:  0417353     Medline TA:  Thorax     Country:  England    
Other Details:
Languages:  eng     Pagination:  933-4     Citation Subset:  IM    
Adult Intensive Care Unit [corrected] Royal Brompton Hospital, London, UK.
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MeSH Terms
Bronchodilator Agents / therapeutic use*
Dyspnea / etiology
Nitric Oxide / therapeutic use*
Piperazines / therapeutic use*
Pulmonary Edema / etiology*
Pulmonary Veno-Occlusive Disease / complications,  drug therapy*
Purines / therapeutic use
Sulfones / therapeutic use*
Tomography, X-Ray Computed
Vasodilator Agents / therapeutic use*
Reg. No./Substance:
0/Bronchodilator Agents; 0/Piperazines; 0/Purines; 0/Sulfones; 0/Vasodilator Agents; 10102-43-9/Nitric Oxide; 139755-83-2/sildenafil
Erratum In:
Thorax. 2009 Jan;64(1):91

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