| Pulmonary veno-occlusive disease presenting with recurrent pulmonary oedema and the use of nitric oxide to predict response to sildenafil. | |
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MedLine Citation:
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PMID: 18820120 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pulmonary veno-occlusive disease (PVOD) is a disorder which causes progressive pulmonary hypertension, usually presenting with worsening dyspnoea and right heart failure. Pulmonary oedema induced by pulmonary vasodilator therapy to reduce pulmonary arterial pressure has been well described in PVOD, but here we describe a case of PVOD presenting with recurrent episodes of acute non-cardiogenic pulmonary oedema, in the absence of significant pulmonary hypertension. Concern over the risk of precipitating pulmonary oedema led us to use inhaled nitric oxide to predict the safety and efficacy of sildenafil. |
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Authors:
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B C Creagh-Brown; A G Nicholson; R Showkathali; J S R Gibbs; L S G E Howard |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Thorax Volume: 63 ISSN: 1468-3296 ISO Abbreviation: Thorax Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-29 Completed Date: 2008-10-27 Revised Date: 2009-01-22 |
Medline Journal Info:
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Nlm Unique ID: 0417353 Medline TA: Thorax Country: England |
Other Details:
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Languages: eng Pagination: 933-4 Citation Subset: IM |
Affiliation:
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Adult Intensive Care Unit [corrected] Royal Brompton Hospital, London, UK. drbencb@gmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Bronchodilator Agents / therapeutic use* Dyspnea / etiology Humans Male Nitric Oxide / therapeutic use* Piperazines / therapeutic use* Pulmonary Edema / etiology* Pulmonary Veno-Occlusive Disease / complications, drug therapy* Purines / therapeutic use Recurrence Sulfones / therapeutic use* Tomography, X-Ray Computed Vasodilator Agents / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Bronchodilator Agents; 0/Piperazines; 0/Purines; 0/Sulfones; 0/Vasodilator Agents; 10102-43-9/Nitric Oxide; 139755-83-2/sildenafil |
| Comments/Corrections | |
Erratum In:
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Thorax. 2009 Jan;64(1):91 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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