Document Detail

Pulmonary veno-occlusive disease after chemotherapy.
MedLine Citation:
PMID:  6187654     Owner:  NLM     Status:  MEDLINE    
A case of pulmonary veno-occlusive disease (PVOD) in a 41-year-old woman who had received chemotherapy (bleomycin, mitomycin-C, and cis-platinum) for metastatic cervical carcinoma is reported. Before her death, pulmonary hypertension and right ventricular heart failure had been attributed to lung toxicity induced by chemotherapy, but the postmortem findings were characteristic of PVOD. The authors support the view that PVOD is a syndrome, not a distinct entity, and present the case as a further example of the many situations in which PVOD can arise. Whether the lesions of the pulmonary veins developed as a result of the chemotherapy or whether the two conditions were associated by chance must remain, for now, a subject of speculation. Pathologists are urged to devote special attention to the examination of the pulmonary vessels in patients who have received chemotherapy.
R Joselson; M Warnock
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Human pathology     Volume:  14     ISSN:  0046-8177     ISO Abbreviation:  Hum. Pathol.     Publication Date:  1983 Jan 
Date Detail:
Created Date:  1983-05-05     Completed Date:  1983-05-05     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9421547     Medline TA:  Hum Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  88-91     Citation Subset:  IM    
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MeSH Terms
Bleomycin / adverse effects
Carcinoma, Squamous Cell / drug therapy
Cisplatin / adverse effects
Cystitis / chemically induced
Lung / pathology
Mitomycins / adverse effects
Pulmonary Veins / pathology*
Thrombosis / chemically induced*,  pathology
Uterine Cervical Neoplasms / drug therapy
Reg. No./Substance:
0/Mitomycins; 11056-06-7/Bleomycin; 15663-27-1/Cisplatin; 50-07-7/Mitomycin

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