Document Detail


Pulmonary veno-occlusive disease after chemotherapy.
MedLine Citation:
PMID:  6187654     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A case of pulmonary veno-occlusive disease (PVOD) in a 41-year-old woman who had received chemotherapy (bleomycin, mitomycin-C, and cis-platinum) for metastatic cervical carcinoma is reported. Before her death, pulmonary hypertension and right ventricular heart failure had been attributed to lung toxicity induced by chemotherapy, but the postmortem findings were characteristic of PVOD. The authors support the view that PVOD is a syndrome, not a distinct entity, and present the case as a further example of the many situations in which PVOD can arise. Whether the lesions of the pulmonary veins developed as a result of the chemotherapy or whether the two conditions were associated by chance must remain, for now, a subject of speculation. Pathologists are urged to devote special attention to the examination of the pulmonary vessels in patients who have received chemotherapy.
Authors:
R Joselson; M Warnock
Related Documents :
17338934 - Combination therapy and new types of agents for pulmonary arterial hypertension.
17536114 - Pathophysiology of pulmonary arterial hypertension.
10214474 - Primary pulmonary hypertension with fatal outcome in a young woman and review of the li...
7449484 - Pulmonary hypertension in polymyositis.
1079134 - Fate of coronary collateral circulation after aorto-coronary saphenous vein bypass grafts.
11239194 - Sustained bilateral hemodynamic benefit of contralateral carotid endarterectomy in pati...
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Human pathology     Volume:  14     ISSN:  0046-8177     ISO Abbreviation:  Hum. Pathol.     Publication Date:  1983 Jan 
Date Detail:
Created Date:  1983-05-05     Completed Date:  1983-05-05     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9421547     Medline TA:  Hum Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  88-91     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Bleomycin / adverse effects
Carcinoma, Squamous Cell / drug therapy
Cisplatin / adverse effects
Cystitis / chemically induced
Female
Humans
Lung / pathology
Mitomycin
Mitomycins / adverse effects
Pulmonary Veins / pathology*
Thrombosis / chemically induced*,  pathology
Uterine Cervical Neoplasms / drug therapy
Chemical
Reg. No./Substance:
0/Mitomycins; 11056-06-7/Bleomycin; 15663-27-1/Cisplatin; 50-07-7/Mitomycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Glutathione S-transferase in human hepatocellular carcinoma.
Next Document:  Early morphologic diagnosis of herpes simplex virus encephalitis: advantages of electron microscopy ...