Document Detail

Pulmonary veno-occlusive disease after autologous bone marrow transplant in a child with stage IV neuroblastoma: case report and literature review.
MedLine Citation:
PMID:  12759629     Owner:  NLM     Status:  MEDLINE    
Pulmonary veno-occlusive disease (PVOD) is a rare, almost universally fatal complication of chemotherapy and bone marrow transplantation with few treatment options. A 19-month-old boy with stage 4 neuroblastoma with fatal PVOD following high-dose chemotherapy with autologous peripheral blood stem cell rescue is described here. A comprehensive literature review revealed 40 case reports of PVOD in oncology patients. Various therapeutic modalities were attempted, with four survivors. PVOD should be considered in patients with dyspnea and cardiomegaly. Less invasive diagnostic methods and more effective therapies are needed.
Angela D Trobaugh-Lotrario; Brian Greffe; Robin Deterding; Gail Deutsch; Ralph Quinones
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Journal of pediatric hematology/oncology     Volume:  25     ISSN:  1077-4114     ISO Abbreviation:  J. Pediatr. Hematol. Oncol.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-05-21     Completed Date:  2003-06-06     Revised Date:  2011-10-06    
Medline Journal Info:
Nlm Unique ID:  9505928     Medline TA:  J Pediatr Hematol Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  405-9     Citation Subset:  IM    
Section of Pediatric Hematology/Oncology/Bone Marrow Transplantation, Children's Hospital of Denver, Colorado, USA.
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MeSH Terms
Bone Marrow Transplantation / adverse effects*
Neoplasm Staging
Neuroblastoma / complications*,  etiology*,  pathology
Pulmonary Veno-Occlusive Disease / complications*,  etiology*,  pathology
Transplantation, Autologous / adverse effects

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