Document Detail

Pulmonary vein antral isolation using an open irrigation ablation catheter for the treatment of atrial fibrillation: a randomized pilot study.
MedLine Citation:
PMID:  17433955     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: We sought to test how catheter ablation using an open irrigation catheter (OIC) compares with standard catheters for pulmonary vein antrum isolation. BACKGROUND: Open irrigation catheters have the advantage of delivering greater power without increasing the temperature of the catheter tip, which enables deeper and wider lesions without the formation of coagulum on catheters. METHODS: Catheter ablation was performed using an 8-mm catheter (8MC) or an OIC. Patients were randomized to 3 groups: 8MC; OIC-1, OIC with a higher peak power (50 W); and OIC-2, OIC with lower peak power (35 W). RESULTS: A total of 180 patients were randomized to the 3 treatment strategies. Isolation of pulmonary vein antra was achieved in all patients. The freedom from atrial fibrillation was significantly greater in the 8MC and OIC-1 groups compared with the OIC-2 group (78%, 82%, and 68%, respectively, p = 0.043). Fluoroscopy time was lower in OIC-1 compared with OIC-2 and 8MC (28 +/- 1 min, 53 +/- 2 min, and 46 +/- 2 min, respectively, p = 0.001). The mean left atrium instrumentation time was lower in the OIC-1 compared with the OIC-2 and 8MC groups (59 +/- 3 min, 90 +/- 5 min, and 88 +/- 4 min, respectively, p = 0.001). However, there was a greater incidence of "pops" in the OIC-1 (100%, 0%, 0%, p < 0.001) along with higher incidences of pericardial effusion (20%, 0%, 0%, p < 0.001) and gastrointestinal complaints (17% in OIC-1, 3% in 8MC, and 5% in OIC-2, p = 0.031). CONCLUSIONS: Although there was a decrease in fluoroscopy and left atrium instrumentation time with the use of OIC at higher power, this setting was associated with increased cardiovascular and gastrointestinal complications.
Mohamed H Kanj; Oussama Wazni; Tamer Fahmy; Sergio Thal; Dimpi Patel; Claude Elay; Luigi Di Biase; Mauricio Arruda; Walid Saliba; Robert A Schweikert; Jennifer E Cummings; J David Burkhardt; David O Martin; Gemma Pelargonio; Antonio Dello Russo; Michela Casella; Pietro Santarelli; Domenico Potenza; Raffaele Fanelli; Raimondo Massaro; Giovanni Forleo; Andrea Natale
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial     Date:  2007-04-02
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  49     ISSN:  1558-3597     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-16     Completed Date:  2007-05-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1634-41     Citation Subset:  AIM; IM    
Cleveland Clinic, Cleveland, Ohio 44195, USA.
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MeSH Terms
Aged, 80 and over
Atrial Fibrillation / diagnosis,  mortality,  surgery*
Catheter Ablation / instrumentation,  methods*
Echocardiography, Doppler
Electrophysiologic Techniques, Cardiac*
Follow-Up Studies
Irrigation / instrumentation
Linear Models
Middle Aged
Pilot Projects
Postoperative Care / methods
Pulmonary Veins / surgery*
Risk Assessment
Severity of Illness Index
Survival Rate
Time Factors
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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