Document Detail

Pulmonary vascular response to high-frequency oscillatory ventilation in dogs: lack of effect of indomethacin.
MedLine Citation:
PMID:  3865235     Owner:  NLM     Status:  MEDLINE    
The role of prostaglandins (PG) in the pulmonary hypertension associated with high-frequency oscillatory ventilation (HFOV) was investigated in 7 pentobarbital-anesthetized dogs. The magnitude and time course of the mean pulmonary artery pressure (PAP) changes induced by HFOV (20 Hz) was quantified before and after PG-production blockade with 15 mg/kg indomethacin (INDO) i.v. It was found that HFOV before INDO induced a 27.2 +/- 5.6% increase in PAP above baseline and a 30.0 +/- 7.2% one hour after INDO administration. This difference was not statistically significant. The time course of the PAP changes induced by HFOV before and after blocking PG-production by INDO were also similar. Mean airway pressure, PaO2 and PaCO2 during HFOV, before and after INDO were not statistically different. It is concluded that the acute increase in PAP induced by HFOV is not due to PG release.
J Armengol; J F Burka; R L Jones; E G King
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Prostaglandins, leukotrienes, and medicine     Volume:  20     ISSN:  0262-1746     ISO Abbreviation:  Prostaglandins Leukot Med     Publication Date:  1985 Oct 
Date Detail:
Created Date:  1986-01-21     Completed Date:  1986-01-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8206868     Medline TA:  Prostaglandins Leukot Med     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  79-88     Citation Subset:  IM    
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MeSH Terms
Indomethacin / pharmacology*
Pulmonary Artery / physiology
Pulmonary Circulation* / drug effects
Pulmonary Wedge Pressure
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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