Document Detail

Pulmonary vascular resistance in dogs and minipigs--effects of hypoxia and inhaled nitric oxide.
MedLine Citation:
PMID:  9574872     Owner:  NLM     Status:  MEDLINE    
The pig has been reported to present with a stronger hypoxic pulmonary vasoconstriction than many other species, including the dog, but it is not known whether this is associated with a different longitudinal partitioning of pulmonary vascular resistance (PVR). We investigated the relationships between cardiac output (Q) and mean pulmonary artery pressure (Ppa) minus occluded Ppa (Ppao), and effective pulmonary capillary pressure (Pc') minus Ppao, in seven minipigs and in seven dogs in hyperoxia (FI(O2) 0.4) and hypoxia (FI(O2) 0.1), first without, then with the inhalation of 80 ppm nitric oxide (NO) to inhibit any reversible component of PVR. Pc' was estimated from the Ppa decay curve following pulmonary artery balloon occlusion. In hyperoxia, minipigs compared to dogs had (Ppa - Ppao)/Q and (Pc' - Ppao)/Q plots shifted to higher pressures. Hypoxia at each level of Q increased Ppa - Ppao in minipigs more than in dogs, and Pc' - Ppao in minipigs only. Inhaled NO reversed hypoxia-induced changes in (Ppa - Ppao)/(Q and (Pc' - Ppao)/Q plots. We conclude that the minipig, compared to the dog, presents with higher PVR and reactivity including vessels downstream to the site of Pc' as determined by the arterial occlusion technique.
M Maggiorini; C Mélot; E Gilbert; F Vermeulen; R Naeije
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respiration physiology     Volume:  111     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-06-15     Completed Date:  1998-06-15     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  213-22     Citation Subset:  IM    
Department of Medicine, University Hospital, Zürich, Switzerland.
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MeSH Terms
Administration, Inhalation
Anoxia / physiopathology*
Blood Pressure / drug effects,  physiology
Cardiac Output / drug effects,  physiology
Hyperoxia / physiopathology
Nitric Oxide / administration & dosage,  pharmacology*
Pulmonary Circulation / drug effects*,  physiology*
Species Specificity
Swine, Miniature
Vascular Resistance / drug effects*,  physiology*
Reg. No./Substance:
10102-43-9/Nitric Oxide

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