Document Detail

Pulmonary vascular involvement in COPD.
MedLine Citation:
PMID:  18842913     Owner:  NLM     Status:  MEDLINE    
Alterations in pulmonary vessel structure and function are highly prevalent in patients with COPD. Vascular abnormalities impair gas exchange and may result in pulmonary hypertension, which is one of the principal factors associated with reduced survival in COPD patients. Changes in pulmonary circulation have been identified at initial disease stages, providing new insight into their pathogenesis. Endothelial cell damage and dysfunction produced by the effects of cigarette smoke products or inflammatory elements is now considered to be the primary alteration that initiates the sequence of events resulting in pulmonary hypertension. Cellular and molecular mechanisms involved in this process are being extensively investigated. Progress in the understanding of the pathobiology of pulmonary hypertension associated with COPD may provide the basis for a new therapeutic approach addressed to correct the imbalance between endothelium-derived vasoactive agents. The safety and efficacy of endothelium-targeted therapy in COPD-associated pulmonary hypertension warrants further investigation in randomized clinical trials.
Víctor I Peinado; Sandra Pizarro; Joan Albert Barberà
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Chest     Volume:  134     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-09     Completed Date:  2008-11-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  808-14     Citation Subset:  AIM; IM    
Department of Pulmonary Medicine, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.
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MeSH Terms
Endothelium, Vascular / pathology*,  physiopathology*
Lung / blood supply*
Pulmonary Circulation / physiology
Pulmonary Disease, Chronic Obstructive / complications,  pathology*,  physiopathology*
Vascular Resistance / physiology
Vasoconstriction / physiology
Vasodilation / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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