| Pulmonary vascular dysfunction in end-stage cystic fibrosis: role of NF-kappaB and endothelin-1. | |
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MedLine Citation:
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PMID: 19460784 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Pulmonary hypertension is rare in chronic respiratory diseases but has a strong impact on the prognosis and is partly underlined by factors other than hypoxaemia. The aim of the present study was to assess the potential role of endothelin-1 (ET-1) and nuclear factor (NF)-kappaB vasoconstrictive pathways in pulmonary hypertension. The effects of ET-1 receptors blockers (BQ 123 and 788) and of genistein were assessed on response to acetylcholine of pulmonary vascular rings from cystic fibrosis (CF) lung transplant recipients (n = 23). NF-kappaB and ET-1 receptor expression was immunodetected in pulmonary arteries and quantitated using Western blotting. ET-1 vascular content was quantitated using ELISA. In total, 14 out of 23 subjects exhibited strongly impaired pulmonary vasodilation (p<0.01 versus nine out of 23 subjects with a normal response) associated with an activation of ET-1 receptors A and NF-kappaB pathways. Genistein restored vasodilation in subjects with an abnormal response. Pulmonary vascular dysfunction is frequent in end-stage CF, involving the NF-kappaB pathway and that of ET-1 through ET-1 receptor A (ETAR). These data leave a conceptual place for ETAR blockers and isoflavones in the management of the devastating vascular complication of chronic obstructive respiratory diseases such as CF. |
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Authors:
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P Henno; C Maurey; C Danel; P Bonnette; R Souilamas; M Stern; C Delclaux; M Lévy; D Israël-Biet |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-05-21 |
Journal Detail:
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Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: 34 ISSN: 1399-3003 ISO Abbreviation: Eur. Respir. J. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-12-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: Switzerland |
Other Details:
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Languages: eng Pagination: 1329-37 Citation Subset: IM |
Affiliation:
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UFR Biomédicale des Saints Pères, UPRES EA 4068, Paris, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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