Document Detail


Pulmonary vascular distensibility predicts aerobic capacity in healthy individuals.
MedLine Citation:
PMID:  22733662     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It has been suggested that shallow slopes of mean pulmonary artery pressure (MPPA)–cardiac output (Q) relationships and pulmonary transit of agitated contrast during exercise may be associated with a higher maximal aerobic capacity V(O(2)max). If so, individuals with a higher V(O(2)max) could also exhibit a higher pulmonary vascular distensibility and increased pulmonary capillary blood volume during exercise. Exercise stress echocardiography was performed with repetitive injections of agitated contrast and measurements of MPPA, Q and lung diffusing capacities for carbon monoxide (D(L,CO)) and nitric oxide (D(L,CO)) in 24 healthy individuals. A pulmonary vascular distensibility coefficient α was mathematically determined from the slight natural curvilinearity of multipoint MPPA–Q plots. Membrane (D(m)) and capillary blood volume (V(c)) components of lung diffusing capacity were calculated. Maximal exercise increased MPPA, cardiac index (CI), D(L,CO) and (D(L,NO). The slope of the linear best fit of MPPA–CI was 3.2 ± 0.5 mmHg min l(-1) m(2) and α was 1.1 ± 0.3% mmHg(-1). A multivariable analysis showed that higher α and greater V(c) independently predicted V(O(2)max). All individuals had markedly positive pulmonary transit of agitated contrast at maximal exercise, with increases proportional to increases in pulmonary capillary pressure and V(c). Pulmonary transit of agitated contrast was not related to pulse oximetry arterial oxygen saturation. Therefore, a more distensible pulmonary circulation and a greater pulmonary capillary blood volume are associated with a higher V(O(2)max) in healthy individuals. Agitated contrast commonly transits through the pulmonary circulation at exercise, in proportion to increased pulmonary capillary pressures.
Authors:
Sophie Lalande; Patrick Yerly; Vitalie Faoro; Robert Naeije
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-06-25
Journal Detail:
Title:  The Journal of physiology     Volume:  590     ISSN:  1469-7793     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-10     Completed Date:  2013-02-11     Revised Date:  2013-09-03    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  4279-88     Citation Subset:  IM    
Affiliation:
Laboratory of Cardiorespiratory Physiology, Faculté des Sciences de la Motricité, Université Libre de Bruxelles, Brussels, Belgium. slaland@uwo.ca
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Volume / physiology
Contrast Media / diagnostic use
Echocardiography, Doppler
Exercise / physiology*
Exercise Test
Female
Humans
Male
Pulmonary Artery / physiology
Pulmonary Circulation / physiology*
Pulmonary Diffusing Capacity / physiology
Vascular Resistance / physiology
Ventricular Function, Right / physiology
Young Adult
Chemical
Reg. No./Substance:
0/Contrast Media
Comments/Corrections
Comment In:
J Physiol. 2013 Feb 1;591(Pt 3):605-6   [PMID:  23378423 ]

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