Document Detail

Pulmonary vascular disease after systemic-pulmonary arterial shunt operations.
MedLine Citation:
PMID:  67797     Owner:  NLM     Status:  MEDLINE    
More than 1,100 patients underwent a systemic-pulmonary arterial shunt operation at the Children's Memorial Hospital, Chicago, from 1946 to 1974. Of these patients, 294 were studied to assess the presence of pulmonary vascular disease and the time of its occurrence after surgery. They were selected either because lung tissue was available for histologic grading of pulmonary vascular disease (114 patients) or because hemodynamic studies were performed after the shunt operation (180 patients). The shunts, all patent at the time of the study, ranged in duration from 1 month to 23 years. After a subclavan-pulmonary arterial shunt (75 patients) there was little evidence of advatients) pulmonary vascular disease in either histologic C2 of 25 patients) or hemodynamic (1 of 50 patients) studies. After an aortic-pulmonary arterial shunt (44 Waterston, 175 Potts) there was small likelikhood of advanced pulmonary vascular disease with a shunt duration of less than 5 years (1 of 35 histologic, 0 of 27 hemodynamic studies). With a shunt duration of more than 5 years the incidence of advanced pulmonary vascular disease increased significantly (15 of 54 histologic, 17 of 103 hemodynamic studies). A mean pulmonary arterial pressure of 50 mm Hg or greater strongly suggests the presence of advanced pulmonary vascular disease. When a systemic-pulmonary arterial shunt has provided effective palliation with decreased pulmonary pressure there is small likelihood that advanced pulmonary vascular disease will develop, even with a long shunt duration of 20 to 25 years.
E A Newfeld; D Waldman; M H paul; A J Muster; R B Cole; F Idriss; W Riker
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  39     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1977 May 
Date Detail:
Created Date:  1977-06-11     Completed Date:  1977-06-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  715-20     Citation Subset:  AIM; IM    
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MeSH Terms
Aorta / surgery*
Follow-Up Studies
Heart Defects, Congenital / surgery*
Lung / blood supply*,  pathology
Palliative Care
Pulmonary Artery / surgery*
Subclavian Artery / surgery*
Thrombosis / etiology*,  pathology
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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