Document Detail


Pulmonary uptake of ropivacaine and levobupivacaine in rabbits.
MedLine Citation:
PMID:  12933424     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Local anesthetic toxicity produced by an inadvertent IV injection is attenuated by the pulmonary uptake of local anesthetics. We compared the pulmonary uptake of ropivacaine and levobupivacaine after a bolus injection in rabbits. Sixteen anesthetized rabbits were randomly assigned to either a ropivacaine group or a levobupivacaine group. A bolus containing ropivacaine or levobupivacaine 0.5 mg/kg and indocyanine green (an intravascular indicator) 0.25 mg/kg was injected rapidly into the vena cava. Arterial blood samples were collected serially at 1.2-s intervals for 30 s. Concentrations of local anesthetic and indocyanine green in each sample were determined for the calculation of first-pass uptake of a local anesthetic in the lung. The first-pass uptake of levobupivacaine (31.4% +/- 8.3%; mean +/- SD) was larger than that of ropivacaine (22.9% +/- 5.6%), and the maximum arterial concentration of ropivacaine (21.2 +/- 2.8 micro g/mL) was larger than that of levobupivacaine (18.6 +/- 1.9 micro g/mL). We conclude that the pulmonary uptake of levobupivacaine is larger than that of ropivacaine after a bolus injection. Therefore, the advantages of ropivacaine over levobupivacaine in terms of less cardiovascular toxicity may be offset by the smaller pulmonary uptake after an inadvertent IV injection.
Authors:
Shigeo Ohmura; Akiko Sugano; Masayuki Kawada; Ken Yamamoto
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  97     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-08-22     Completed Date:  2003-09-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  893-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Anesthesiology and Intensive Care Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan. ohmura@med.kanazawa-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Amides / administration & dosage,  pharmacokinetics*
Anesthesia
Anesthetics, Local / administration & dosage,  pharmacokinetics*
Animals
Biotransformation
Coloring Agents
Indocyanine Green
Injections
Injections, Intravenous
Lung / metabolism*
Male
Rabbits
Stereoisomerism
Chemical
Reg. No./Substance:
0/Amides; 0/Anesthetics, Local; 0/Coloring Agents; 3599-32-4/Indocyanine Green; 84057-95-4/ropivacaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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