| Pulmonary uptake of ropivacaine and levobupivacaine in rabbits. | |
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MedLine Citation:
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PMID: 12933424 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Local anesthetic toxicity produced by an inadvertent IV injection is attenuated by the pulmonary uptake of local anesthetics. We compared the pulmonary uptake of ropivacaine and levobupivacaine after a bolus injection in rabbits. Sixteen anesthetized rabbits were randomly assigned to either a ropivacaine group or a levobupivacaine group. A bolus containing ropivacaine or levobupivacaine 0.5 mg/kg and indocyanine green (an intravascular indicator) 0.25 mg/kg was injected rapidly into the vena cava. Arterial blood samples were collected serially at 1.2-s intervals for 30 s. Concentrations of local anesthetic and indocyanine green in each sample were determined for the calculation of first-pass uptake of a local anesthetic in the lung. The first-pass uptake of levobupivacaine (31.4% +/- 8.3%; mean +/- SD) was larger than that of ropivacaine (22.9% +/- 5.6%), and the maximum arterial concentration of ropivacaine (21.2 +/- 2.8 micro g/mL) was larger than that of levobupivacaine (18.6 +/- 1.9 micro g/mL). We conclude that the pulmonary uptake of levobupivacaine is larger than that of ropivacaine after a bolus injection. Therefore, the advantages of ropivacaine over levobupivacaine in terms of less cardiovascular toxicity may be offset by the smaller pulmonary uptake after an inadvertent IV injection. |
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Authors:
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Shigeo Ohmura; Akiko Sugano; Masayuki Kawada; Ken Yamamoto |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Anesthesia and analgesia Volume: 97 ISSN: 0003-2999 ISO Abbreviation: Anesth. Analg. Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2003-08-22 Completed Date: 2003-09-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1310650 Medline TA: Anesth Analg Country: United States |
Other Details:
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Languages: eng Pagination: 893-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Anesthesiology and Intensive Care Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan. ohmura@med.kanazawa-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Amides / administration & dosage, pharmacokinetics* Anesthesia Anesthetics, Local / administration & dosage, pharmacokinetics* Animals Biotransformation Coloring Agents Indocyanine Green Injections Injections, Intravenous Lung / metabolism* Male Rabbits Stereoisomerism |
| Chemical | |
Reg. No./Substance:
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0/Amides; 0/Anesthetics, Local; 0/Coloring Agents; 3599-32-4/Indocyanine Green; 84057-95-4/ropivacaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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