Document Detail

Pulmonary tumor thrombotic microangiopathy.
MedLine Citation:
PMID:  7581935     Owner:  NLM     Status:  MEDLINE    
Pulmonary tumor thrombotic microangiopathy (PTTM) is characterized by widespread fibrocellular intimal proliferation of the small pulmonary arteries and arterioles in patients with metastatic carcinoma. Microscopic pulmonary tumor emboli have frequently occurred in patients with malignant tumors; however, few cases of PTTM have been reported. A rare case of a patient with gastric adenocarcinoma who presented with acute dyspnea and lethal respiratory failure is described. Histologically, diffuse fibromuscular intimal thickening causing luminal stenosis and obstruction but containing rather few cancer cells was observed in the small pulmonary arteries and arterioles. These findings were consistent with PTTM. Although PTTM is a rare phenomenon, PTTM should be considered in the differential diagnosis of acute dyspnea or pulmonary hypertension in patients with carcinoma.
Y Sato; K Marutsuka; Y Asada; M Yamada; T Setoguchi; A Sumiyoshi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pathology international     Volume:  45     ISSN:  1320-5463     ISO Abbreviation:  Pathol. Int.     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-12-13     Completed Date:  1995-12-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9431380     Medline TA:  Pathol Int     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  436-40     Citation Subset:  IM    
First Department of Pathology, Miyazaki Medical College, Japan.
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MeSH Terms
Adenocarcinoma / complications
Lung / blood supply*,  pathology
Lung Neoplasms / complications,  pathology*,  secondary
Microcirculation / pathology
Middle Aged
Stomach Neoplasms / complications
Thrombosis / etiology*,  pathology

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