| Pulmonary transfusion reactions. | |
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MedLine Citation:
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PMID: 17198842 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Transfusion reactions remain a common complication of transfusion therapy; reactions affecting the lungs are some of the most serious. Several different mechanisms are responsible for pulmonary transfusion reactions, and most cause adverse effects in addition to lung injury. Fluid overload can lead to pulmonary edema, antibodies reacting with plasma proteins can cause bronchospasm and anaphylaxis, and particulate matter can produce microemboli. These reactions are well understood and usually can be prevented. Transfusions are also associated with acute lung injury and acute respiratory distress syndrome (ARDS), but their etiology is poorly understood and they remain clinically problematic. Neutrophil antibodies cause some of these serious as well as mild pulmonary reactions, but the exact role of leukocyte antibodies in pulmonary reactions remains unclear. Other blood donor, blood component, and transfusion recipient factors likely play a contributing or modulating role in pulmonary transfusion reactions, but prospective studies are needed to better understand their role. |
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Authors:
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David F Stroncek |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Seminars in hematology Volume: 44 ISSN: 0037-1963 ISO Abbreviation: Semin. Hematol. Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2007-01-02 Completed Date: 2007-02-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404514 Medline TA: Semin Hematol Country: United States |
Other Details:
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Languages: eng Pagination: 2-14 Citation Subset: IM |
Affiliation:
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Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892-1184, USA. dstroncek@cc.nih.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Component Transfusion
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adverse effects* Blood Donors Case-Control Studies Hemolysis / physiology Humans Hypersensitivity / physiopathology Pulmonary Circulation / physiology Respiratory Distress Syndrome, Adult / immunology*, physiopathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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