Document Detail


Pulmonary toxicity with oxaliplatin and capecitabine/5-Fluorouracil chemotherapy: a case report and review of the literature.
MedLine Citation:
PMID:  21934344     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Oxaliplatin in combination with either 5-fluorouracil or capecitabine is commonly used in the treatment of colorectal cancer and is rarely associated with pulmonary toxicity. This is the first reported case of oxaliplatin and capecitabine/5-fluorouracil causing pulmonary toxicity in a patient with pre-existing asymptomatic interstitial lung disease.
CASE REPORT: We report a case of a man who was treated with oxaliplatin and capecitabine for 1 cycle, then subsequently with oxaliplatin and 5-fluorouracil following a resected Dukes' C colon carcinoma. His preoperative computed tomography scan incidentally showed mild pulmonary interstitial changes for which he was asymptomatic. He developed pulmonary fibrosis during the course of his chemotherapy, and therefore further chemotherapy was stopped. He was treated with high dose steroids and immunosuppressants which initially stabilized his respiratory symptoms.
CONCLUSIONS: Pulmonary fibrosis is a rare complication of oxaliplatin and capecitabine/5-fluorouracil. With the widespread use of oxaliplatin combinations in colorectal cancer, active assessment for interstitial lung disease is recommended and caution in its use should be exercised in those with pre-existing interstitial lung disease.
Authors:
Andrew K Chan; Bok A Choo; John Glaholm
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2011-08-19
Journal Detail:
Title:  Onkologie     Volume:  34     ISSN:  1423-0240     ISO Abbreviation:  Onkologie     Publication Date:  2011  
Date Detail:
Created Date:  2011-09-21     Completed Date:  2012-03-12     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  7808556     Medline TA:  Onkologie     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  443-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 S. Karger AG, Basel.
Affiliation:
Cancer Centre, Queen Elizabeth Hospital, Birmingham, United Kingdom. andrewchan@doctors.org.uk
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MeSH Terms
Descriptor/Qualifier:
Aged
Antineoplastic Combined Chemotherapy Protocols / therapeutic use,  toxicity*
Chemotherapy, Adjuvant
Colectomy
Deoxycytidine / administration & dosage,  analogs & derivatives,  toxicity
Drug Administration Schedule
Dyspnea / chemically induced
Fluorouracil / administration & dosage,  analogs & derivatives,  toxicity
Humans
Lung / drug effects*,  radiography
Lung Diseases, Interstitial / complications,  radiography
Lung Volume Measurements
Male
Neoplasms / drug therapy*,  surgery
Organoplatinum Compounds / administration & dosage,  toxicity
Pulmonary Fibrosis / chemically induced*,  radiography
Tomography, X-Ray Computed
Chemical
Reg. No./Substance:
0/Organoplatinum Compounds; 51-21-8/Fluorouracil; 63121-00-6/oxaliplatin; 6804DJ8Z9U/capecitabine; 951-77-9/Deoxycytidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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