Document Detail

Pulmonary thrombosis in steroid-sensitive nephrotic syndrome.
MedLine Citation:
PMID:  15778847     Owner:  NLM     Status:  MEDLINE    
Thrombo-embolic episodes are an uncommon but known complication of nephrotic syndrome. However, pulmonary thrombosis/thromboembolism is rare, especially in children. We describe the cases of two girls, aged 12 years, who presented with severe oedema in relapse. They had intermittent tachypnoea, and CT pulmonary angiography (CTPA) provided a less invasive and more definitive way of confirming pulmonary thrombosis/thromboembolism. They received heparin with resolution of the tachypnoea. Anticoagulation was continued for 6 months after the episode in one patient. They have been in remission for more than 1 year, and a thrombophilia screen does not indicate a predisposing tendency to the formation of clots. Pulmonary thrombosis/thromboembolism could present with subtle symptoms and needs prompt diagnosis and treatment to prevent a fatal outcome.
Pankaj V Deshpande; Mark Griffiths
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2005-03-19
Journal Detail:
Title:  Pediatric nephrology (Berlin, Germany)     Volume:  20     ISSN:  0931-041X     ISO Abbreviation:  Pediatr. Nephrol.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-04-19     Completed Date:  2005-07-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8708728     Medline TA:  Pediatr Nephrol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  665-9     Citation Subset:  IM    
Department of Paediatric Nephrology, Southampton University Hospitals Trust, Tremona Road, Southampton, S016 6YD, UK.
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MeSH Terms
Anticoagulants / therapeutic use
Heparin / therapeutic use
Nephrotic Syndrome / complications*,  drug therapy
Pulmonary Embolism / complications*,  drug therapy
Steroids / therapeutic use
Reg. No./Substance:
0/Anticoagulants; 0/Steroids; 9005-49-6/Heparin

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