| Pulmonary thromboembolism during therapy of dirofilariasis with thiacetarsamide: modification with aspirin or prednisolone. | |
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MedLine Citation:
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PMID: 6881666 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects that 4 weeks of treatment of dirofilaria-infected dogs with either aspirin or prednisolone had on the pulmonary thromboembolism which occurs after they are given thiacetarsamide were determined, using light and electron microscopies. Pulmonary lesions in control dogs at 4 weeks after thiacetarsamide was given were compared with lesions in dogs which were treated with either aspirin (22 mg/kg daily) or prednisolone (1 mg/kg daily) during the 4-week period after adulticide was given. Pulmonary vascular and perivascular lesions were most severe in the prednisolone-treated dogs and least severe in the aspirin-treated dogs. The aspirin-treated dogs had greater resolution of pulmonary arterial proliferative disease, and prednisolone-treated dogs had the lesser resolution. |
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Authors:
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J C Keith; C A Rawlings; R G Schaub |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of veterinary research Volume: 44 ISSN: 0002-9645 ISO Abbreviation: Am. J. Vet. Res. Publication Date: 1983 Jul |
Date Detail:
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Created Date: 1983-09-23 Completed Date: 1983-09-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375011 Medline TA: Am J Vet Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1278-83 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arsenamide / adverse effects*, therapeutic use Arsenicals / adverse effects* Aspirin / therapeutic use* Dirofilariasis / drug therapy, pathology, veterinary* Dog Diseases / drug therapy* Dogs Drug Interactions Lung / pathology Microscopy, Electron, Scanning Prednisolone / therapeutic use* Pulmonary Artery / ultrastructure Pulmonary Embolism / drug therapy, pathology, veterinary* |
| Chemical | |
Reg. No./Substance:
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0/Arsenicals; 50-24-8/Prednisolone; 50-78-2/Aspirin; 531-72-6/Arsenamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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