Document Detail

Pulmonary thromboembolism during therapy of dirofilariasis with thiacetarsamide: modification with aspirin or prednisolone.
MedLine Citation:
PMID:  6881666     Owner:  NLM     Status:  MEDLINE    
The effects that 4 weeks of treatment of dirofilaria-infected dogs with either aspirin or prednisolone had on the pulmonary thromboembolism which occurs after they are given thiacetarsamide were determined, using light and electron microscopies. Pulmonary lesions in control dogs at 4 weeks after thiacetarsamide was given were compared with lesions in dogs which were treated with either aspirin (22 mg/kg daily) or prednisolone (1 mg/kg daily) during the 4-week period after adulticide was given. Pulmonary vascular and perivascular lesions were most severe in the prednisolone-treated dogs and least severe in the aspirin-treated dogs. The aspirin-treated dogs had greater resolution of pulmonary arterial proliferative disease, and prednisolone-treated dogs had the lesser resolution.
J C Keith; C A Rawlings; R G Schaub
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of veterinary research     Volume:  44     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  1983 Jul 
Date Detail:
Created Date:  1983-09-23     Completed Date:  1983-09-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1278-83     Citation Subset:  IM    
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MeSH Terms
Arsenamide / adverse effects*,  therapeutic use
Arsenicals / adverse effects*
Aspirin / therapeutic use*
Dirofilariasis / drug therapy,  pathology,  veterinary*
Dog Diseases / drug therapy*
Drug Interactions
Lung / pathology
Microscopy, Electron, Scanning
Prednisolone / therapeutic use*
Pulmonary Artery / ultrastructure
Pulmonary Embolism / drug therapy,  pathology,  veterinary*
Reg. No./Substance:
0/Arsenicals; 50-24-8/Prednisolone; 50-78-2/Aspirin; 531-72-6/Arsenamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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