Document Detail

Pulmonary thromboembolism. 2. New trends in prophylaxis and therapy.
MedLine Citation:
PMID:  7375411     Owner:  NLM     Status:  MEDLINE    
Although low-dose heparin therapy is the technique most commonly used for prophylaxis of pulmonary thromboembolism, its usefulness is being questioned. Platelet deaggregation prophylaxis with either aspirin or dipyridamole, or both, apparently is a reasonable alternative, but further studies are needed. For treatment of pulmonary thromboembolism, continuous conventional-dose heparin therapy is the approach of choice. It has the highest therapeutic/toxic ratio and is the most effective technique for prevention of clot propagation. The patient's fibrinolytic network must be intact, however, if clot degradation is to occur. Fibrinolytic therapy with urokinase or streptokinase should be restricted to use in patients with massive pulmonary embolism in whom hemodynamics are unstable. Caval interruption and pulmonary embolectomy have lower benefit/risk ratios than do the medical alternatives and are rarely used for pulmonary thromboembolism.
J C Giudice; H J Komansky; J Kaufman
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Postgraduate medicine     Volume:  67     ISSN:  0032-5481     ISO Abbreviation:  Postgrad Med     Publication Date:  1980 May 
Date Detail:
Created Date:  1980-07-22     Completed Date:  1980-07-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401147     Medline TA:  Postgrad Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  81-3, 86-9     Citation Subset:  AIM; IM    
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MeSH Terms
Aspirin / therapeutic use
Dipyridamole / therapeutic use
Fibrinolytic Agents / therapeutic use
Heparin / adverse effects,  therapeutic use
Platelet Aggregation / drug effects
Pulmonary Embolism / drug therapy*,  prevention & control,  surgery
Vena Cava, Inferior / surgery
Reg. No./Substance:
0/Fibrinolytic Agents; 50-78-2/Aspirin; 58-32-2/Dipyridamole; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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