Document Detail

Pulmonary and systemic vascular responses to nitrous oxide in patients with mitral stenosis and pulmonary hypertension.
MedLine Citation:
PMID:  7189378     Owner:  NLM     Status:  MEDLINE    
Pulmonary and systemic circulatory responses to inhalation of 50% nitrous oxide were studied in 11 patients with pulmonary hypertension prior to elective mitral valve replacement. All patients were premedicated with intramuscular morphine and scopolamine. Compared with awake control measurements while breathing 50% oxygen in nitrogen, heart rate, cardiac index, systemic and pulmonary vascular pressures, systemic vascular resistance, and systemic and pulmonary heart rate, systolic blood pressure products remained unchanged after administration of 50% nitrous oxide for 10 minutes. The only significant change was an increase in pulmonary vascular resistance from 159 +/- 18 before nitrous oxide inhalation to 213 +/- 27 during nitrous oxide inhalation (p less than 0.05). We conclude that nitrous oxide increases pulmonary vascular resistance in patients with preexisting pulmonary hypertension; however, this increase is not associated with alterations in other measured or calculated hemodynamic variables and is probably not of sufficient magnitude to recommend avoiding nitrous oxide in these patients.
J C Hilgenberg; R L McCammon; R K Stoelting
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  59     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1980 May 
Date Detail:
Created Date:  1980-06-25     Completed Date:  1980-06-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  323-6     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Pressure / drug effects
Cardiac Output / drug effects
Heart Rate / drug effects
Hypertension, Pulmonary / complications,  physiopathology*
Middle Aged
Mitral Valve Stenosis / complications,  physiopathology*
Nitrous Oxide / pharmacology*
Pulmonary Circulation / drug effects*
Vascular Resistance / drug effects*
Reg. No./Substance:
10024-97-2/Nitrous Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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