Document Detail

Pulmonary and systemic effects of inhaled endotoxin in control and heaves horses.
MedLine Citation:
PMID:  11352355     Owner:  NLM     Status:  MEDLINE    
To investigate whether inhaled endotoxin contributes to airway inflammation and dysfunction in stabled horses, control (n = 6) and asymptomatic heaves (previously termed chronic obstructive pulmonary disease)-susceptible (n = 7) horses were given inhalation challenges with 20, 200 and 2,000 microg of soluble Salmonella typhimurium Ra60 lipopolysaccharide (LPS). LPS inhalation induced a dose-dependent neutrophilic airway inflammatory response in both groups. Inhalation with 2,000 microg of LPS also induced detectable lung dysfunction in the heaves group. LPS inhalation did not alter clinical score, tracheal secretion volume or airway reactivity in either group. The no-response thresholds were lower for the heaves group (<20 microg for airway inflammation; 200 to 2,000 microg for lung dysfunction) than for the control group (20 to 200 microg for airway inflammation; >2,000 microg for lung dysfunction). To enable comparison of these threshold levels with airborne endotoxin concentrations in stables, horses also received a 5 h duration hay/straw challenge, during which the total and respirable airborne endotoxin concentrations were determined. Comparison of the effects of acute LPS inhalation and hay/straw challenges suggest that inhaled endotoxin is not the sole cause of heaves. However, it is likely that it contributes to airway inflammation, both in heaves horses in concert with other inhalants, and in normal horses when they are exposed to high levels in poor stable environments.
R S Pirie; P M Dixon; D D Collie; B C McGorum
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Equine veterinary journal     Volume:  33     ISSN:  0425-1644     ISO Abbreviation:  Equine Vet. J.     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-05-15     Completed Date:  2001-12-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0173320     Medline TA:  Equine Vet J     Country:  England    
Other Details:
Languages:  eng     Pagination:  311-8     Citation Subset:  IM    
Wellcome Trust Centre for Research in Comparative Respiratory Medicine, University of Edinburgh, Roslin, Midlothian, UK.
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MeSH Terms
Case-Control Studies
Dose-Response Relationship, Drug
Endotoxins / toxicity*
Horse Diseases / chemically induced,  etiology*
Horses / physiology*
Housing, Animal*
Inhalation Exposure
Lipopolysaccharides / toxicity
Lung / drug effects*
Pulmonary Disease, Chronic Obstructive / etiology,  veterinary*
Reg. No./Substance:
0/Endotoxins; 0/Lipopolysaccharides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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