Document Detail

Pulmonary sarcoidosis and antiphospholipid syndrome.
MedLine Citation:
PMID:  16771926     Owner:  NLM     Status:  MEDLINE    
Various autoimmune diseases have been reported to occur in patients with sarcoidosis. However, coexistence of sarcoidosis and antiphospholipid syndrome (APS) is extremely rare. We describe a 59-year-old female patient with pulmonary sarcoidosis who had preceding APS. Her previous medical history consisted of a miscarriage and ischemic colitis. She was diagnosed as APS during the onset of a brainstem infarction with positive reaction to beta2-glycoprotein I-dependent anticardiolipin antibody. Two years later, chest CT revealed enlargement of the hilar and mediastinal lymph nodes and small nodules in the lung fields. Transbronchial lung biopsy demonstrated non-caseating epithelioid cell granuloma leading to the diagnosis of definite pulmonary sarcoidosis. This is the first APS case where pulmonary involvement with sarcoidosis has been confirmed through lung biopsy. Our case report suggests that APS should be recognized as an accompanying disorder of sarcoidosis.
Fumiyuki Takahashi; Michie Toba; Kazuhisa Takahashi; Shigeru Tominaga; Koichi Sato; Yoshiteru Morio; Yuta Nakao; Ken Tajima; Kayo Miura; Toshimasa Uekusa; Yoshinosuke Fukuchi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Respirology (Carlton, Vic.)     Volume:  11     ISSN:  1323-7799     ISO Abbreviation:  Respirology     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-06-14     Completed Date:  2006-11-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9616368     Medline TA:  Respirology     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  506-8     Citation Subset:  IM    
Department of Respiratory Medicine, Juntendo University, School of Medicine, Hongo, Tokyo, Japan.
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MeSH Terms
Ambulatory Care Facilities
Antiphospholipid Syndrome / diagnosis*
Follow-Up Studies
Glycoproteins / immunology
Granuloma / pathology
Lung / pathology,  radiography,  surgery
Lymph Nodes / radiography
Middle Aged
Sarcoidosis, Pulmonary / diagnosis*,  pathology
Time Factors
Tomography, X-Ray Computed
beta 2-Glycoprotein I
Reg. No./Substance:
0/Glycoproteins; 0/beta 2-Glycoprotein I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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