Document Detail

Pulmonary sarcoid-like granulomata in a patient treated for extrapulmonary Hodgkin's disease.
MedLine Citation:
PMID:  9044487     Owner:  NLM     Status:  MEDLINE    
We report a case of interstitial lung disease developing during treatment with chlorambucil, vinblastine, procarbazine and prednisone for extrapulmonary Hodgkin's disease. Transbronchial biopsies demonstrated noncaseating epithelioid cell granulomata, and bronchoalveolar lavage fluid showed an increased percentage of lymphocytes, with a raised T cell helper-suppressor ratio, suggesting a diagnosis of sarcoidosis. Treatment with corticosteroids brought about complete resolution of the radiographic lesions. A possible relationship between sarcoidosis and lymphoma is discussed, and a short review of the literature is given. This case report has some unique features that, to our knowledge, have not been published before.
van den Berg; M Fickers; P Theunissen; J A van Noord
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Respiration; international review of thoracic diseases     Volume:  64     ISSN:  0025-7931     ISO Abbreviation:  Respiration     Publication Date:  1997  
Date Detail:
Created Date:  1997-05-05     Completed Date:  1997-05-05     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0137356     Medline TA:  Respiration     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  114-7     Citation Subset:  IM    
Department of Respiratory Diseases, De Wever Hospital, Heerlen, The Netherlands.
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MeSH Terms
Anti-Inflammatory Agents / therapeutic use
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Bronchoalveolar Lavage Fluid / cytology
Hodgkin Disease / complications,  drug therapy*
Lung / pathology,  radiography
Prednisone / therapeutic use
Remission Induction
Sarcoidosis, Pulmonary / diagnosis,  drug therapy,  etiology*
Tomography, X-Ray Computed
Reg. No./Substance:
0/Anti-Inflammatory Agents; 53-03-2/Prednisone

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